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Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366300, updated on 27-Nov-2024

Summary

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Official Symbol
Pcmtd1provided by RGD
Official Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1provided by RGD
Primary source
RGD:1586096
See related
EnsemblRapid:ENSRNOG00000005730 AllianceGenome:RGD:1586096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307986
Summary
Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in protein ubiquitination. Predicted to be located in membrane. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human PCMTD1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 355.2), Spleen (RPKM 318.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pcmtd1 in Genome Data Viewer
Location:
5q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (17071629..17143803, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (12284711..12355680, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (12132657..12204376, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 2 Neighboring gene uncharacterized LOC120102811 Neighboring gene TOR signaling pathway regulator, pseudogene 2 Neighboring gene ribosomal protein S15, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-L-isoaspartate O-methyltransferase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257345.1 → NP_001244274.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1

    See identical proteins and their annotated locations for NP_001244274.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JFH4, D3ZPI9, D4A629
    Related
    ENSRNOP00000058618.2, ENSRNOT00000061903.4
    Conserved Domains (1) summary
    pfam01135
    Location:11 → 219
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    17071629..17143803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593529.3 → XP_017449018.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JFH5
    Conserved Domains (1) summary
    COG2518
    Location:5 → 44
    Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

  2. XM_039110458.2 → XP_038966386.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JFH5
    Conserved Domains (1) summary
    COG2518
    Location:5 → 44
    Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

  3. XM_039110459.2 → XP_038966387.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JFH5
    Conserved Domains (1) summary
    COG2518
    Location:5 → 44
    Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

  4. XM_039110457.2 → XP_038966385.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6JFH4, D3ZPI9, D4A629
    Conserved Domains (1) summary
    pfam01135
    Location:11 → 219
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

  5. XM_008763515.4 → XP_008761737.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JFH5
    Conserved Domains (1) summary
    COG2518
    Location:5 → 44
    Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version

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