Aqr aquarius intron-binding spliceosomal factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqrprovided by RGD
Official Full Name: aquarius intron-binding spliceosomal factorprovided by RGD
Primary source: RGD:1306223
See related: EnsemblRapid:ENSRNOG00000008912 AllianceGenome:RGD:1306223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 143.3), Spleen (RPKM 127.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (121329287..121399375, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (100874987..100945026, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (105570399..105640431, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137108 (e-PCR)
- UniSTS:219196

BF400060 (e-PCR)
- UniSTS:244825

AW495846 (e-PCR)
- UniSTS:178676

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U2-type catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA helicase aquarius

Names: aquarius homolog; intron-binding protein aquarius

NP_001094457.1

EC 3.6.4.13

XP_063140346.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100987.1 → NP_001094457.1 RNA helicase aquarius

See identical proteins and their annotated locations for NP_001094457.1

Status: PROVISIONAL

Source sequence(s)

BC133727

UniProtKB/TrEMBL

A3KNA0, A6HP78, A6HP79, F7FAP1

Related

ENSRNOP00000011950.5, ENSRNOT00000011952.8

Conserved Domains (4) summary

pfam13086
Location:805 → 1107

AAA_11; AAA domain

pfam13245
Location:808 → 880

AAA_19; Part of AAA domain

pfam16399
Location:18 → 802

Aquarius_N; Intron-binding protein aquarius N-terminus

cl22977
Location:1115 → 1304

UvrD_C_2; UvrD-like helicase C-terminal domain