Asx - Additional sex combs

Enables chromatin binding activity and deubiquitinase activator activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in chromatin and nucleus. Part of PR-DUB complex. Is expressed in central nervous system; nurse cell; organism; and ventral neurectoderm. Human ortholog(s) of this gene implicated in Bainbridge-Ropers syndrome; SM-AHNMD; and hematologic cancer (multiple). Orthologous to several human genes including ASXL1 (ASXL transcriptional regulator 1) and ASXL2 (ASXL transcriptional regulator 2). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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