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Dh44-R1 Diuretic hormone 44 receptor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36601, updated on 4-Jan-2025

Summary

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Official Symbol
Dh44-R1provided by FlyBase
Official Full Name
Diuretic hormone 44 receptor 1provided by FlyBase
Primary source
FLYBASE:FBgn0033932
Locus tag
Dmel_CG8422
See related
AllianceGenome:FB:FBgn0033932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.100; anon-WO0170980.101; CG8422; DH-R; DH44-R1; Dh44R1; DH44R1; DH[[44]]-R1; DmeCG8422; Dmel\CG8422
Summary
Enables diuretic hormone receptor activity. Involved in G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult abdominal neuromere; adult brain; central nervous system; larval MP3 neuron; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including LINC02210-CRHR1 (LINC02210-CRHR1 readthrough) and CRHR1 (corticotropin releasing hormone receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Dh44-R1 in Genome Data Viewer
Location:
50F8-50F9; 2-70 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14378097..14385359)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10265602..10272864)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 50e Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans. Cardoso JC, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 25230393
  2. Repetitive aggressive encounters generate a long-lasting internal state in Drosophila melanogaster males. Kim YK, et al. Proc Natl Acad Sci U S A, 2018 Jan 30. PMID 29339481, Free PMC Article
  3. Overlapping Central Clock Network Circuitry Regulates Circadian Feeding and Activity Rhythms in Drosophila. Saurabh S, et al. J Biol Rhythms, 2024 Oct. PMID 39066485
  4. Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF. Hyun S, et al. Neuron, 2005 Oct 20. PMID 16242407
  5. Nematode and arthropod genomes provide new insights into the evolution of class 2 B1 GPCRs. Cardoso JC, et al. PLoS One, 2014. PMID 24651821, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster.
    Title: A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster.
  2. The DH44 PI-Hugin SEZ circuit controls circadian locomotor activity in a daily cycle but has minimal effect on feeding rhythms, suggesting that the circadian drive to feed can be separated from circadian locomotion.
    Title: A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.
  3. The Dh44/DH44 receptor system directs the detection and consumption of nutritive sugars through a positive feedback loop.
    Title: Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.
  4. Fundamental differences in signaling, association with the arrestins, and peptide sensitivity between CG8422 and CG12370 are discussed.
    Title: Functional differences between two CRF-related diuretic hormone receptors in Drosophila.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcitonin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables diuretic hormone receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diuretic hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables diuretic hormone receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables diuretic hormone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables neuropeptide receptor activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
diuretic hormone 44 receptor 1
Names
CG8422-PA
CRF-like diuretic hormone receptor 1
DH44 receptor
DH44-receptor
DH[[44]] receptor
Dh44 receptor 1
Dh44-R1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14378097..14385359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137116.3 → NP_610960.1  diuretic hormone 44 receptor 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9Q8
    Related
    FBpp0086614
    Conserved Domains (2) summary
    cd15263
    Location:126 → 394
    7tmB1_DH_R; insect diuretic hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:52 → 112
    HRM; Hormone receptor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z9Q8 A1Z9Q8
Q8SWX5 Q8SWX5

Gene LinkOut

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