U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tej tejas [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36590, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
tejprovided by FlyBase
Official Full Name
tejasprovided by FlyBase
Primary source
FLYBASE:FBgn0033921
Locus tag
Dmel_CG8589
See related
AllianceGenome:FB:FBgn0033921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe1D11; CG8589; Dmel\CG8589; TDRD5; Tej; Tejas
Summary
Involved in piRNA-mediated retrotransposon silencing by mRNA destabilization and secondary piRNA processing. Located in P granule. Orthologous to human TDRD5 (tudor domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tej in Genome Data Viewer
Location:
50F1-50F1; 2-70 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14300103..14302353, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10187608..10189858, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene convoluted Neighboring gene I[[h]] channel Neighboring gene Shroom Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Jeske M, et al. Genes Dev, 2017 May 1. PMID 28536148, Free PMC Article
  2. Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis. Lin Y, et al. J Cell Biol, 2023 Oct 2. PMID 37555815, Free PMC Article
  3. Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal. Primus S, et al. PLoS Genet, 2019 Jul. PMID 31329582, Free PMC Article
  4. Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Webster A, et al. Mol Cell, 2015 Aug 20. PMID 26295961, Free PMC Article
  5. Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas. Patil VS, et al. Curr Biol, 2010 Apr 27. PMID 20362446

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis.
    Title: Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis.
  2. Data suggest that Tejas contributes to the formation of a macromolecular complex at perinuclear region and engages it in the production of germline piRNAs.
    Title: Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in secondary piRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in secondary piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transposable element silencing by mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transposable element silencing by piRNA-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tejas
Names
CG8589-PA
anon-fast-evolving-1D11
tej-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14300103..14302353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137106.3 → NP_610950.2  tejas [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610950.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9P1
    Related
    FBpp0086689
    Conserved Domains (2) summary
    cd09972
    Location:7 → 93
    LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7
    pfam00567
    Location:379 → 488
    TUDOR; Tudor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z9P1 A1Z9P1
Q8SZ14 Q8SZ14

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools