U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spopfm2l2 speckle-type BTB/POZ protein family member 2 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365855, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Spopfm2l2provided by RGD
Official Full Name
speckle-type BTB/POZ protein family member 2 like 1provided by RGD
Primary source
RGD:1563667
See related
EnsemblRapid:ENSRNOG00000085967 AllianceGenome:RGD:1563667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tdpoz-T2; RGD1563667
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 9.8), Kidney (RPKM 4.5) and 7 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Spopfm2l2 in Genome Data Viewer
Location:
2q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (184568613..184642576, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (181879554..181953471, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (195152284..195554013, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (117465991..117467757, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene TD and POZ domain containing 1, pseudogene 5 Neighboring gene speckle-type BTB/POZ protein family member 2 like 1 Neighboring gene zinc finger CCCH-type containing 11A, pseudogene 3 Neighboring gene thioesterase superfamily member 4 Neighboring gene thioesterase superfamily member 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Testis-specific expression and genomic multiplicity of the rat Rtdpoz genes that encode bipartite TRAF- and POZ/BTB-domain proteins. Choo KB, et al. Gene, 2007 Jan 31. PMID 17071022
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
RAF domain and POZ/BTB containing protein T2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100985.2 → NP_001094455.2  RAF domain and POZ/BTB containing protein T2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    B5TQV7, E9PTZ3
    Related
    ENSRNOP00000098545.2, ENSRNOT00000120972.2
    Conserved Domains (3) summary
    cl02446
    Location:16 → 154
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:165 → 292
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:287 → 351
    BACK; BACK (BTB and C-terminal Kelch) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    184568613..184642576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102776.2 → XP_038958704.1  RAF domain and POZ/BTB containing protein T2 isoform X1

    UniProtKB/TrEMBL
    B5TQV7, E9PTZ3
    Related
    ENSRNOP00000040923.6, ENSRNOT00000048323.7
    Conserved Domains (3) summary
    cl02446
    Location:16 → 154
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:165 → 292
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:287 → 351
    BACK; BACK (BTB and C-terminal Kelch) domain

  2. XM_039102777.2 → XP_038958705.1  RAF domain and POZ/BTB containing protein T2 isoform X1

    UniProtKB/TrEMBL
    B5TQV7, E9PTZ3
    Conserved Domains (3) summary
    cl02446
    Location:16 → 154
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:165 → 292
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:287 → 351
    BACK; BACK (BTB and C-terminal Kelch) domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.