Rab33b RAB33B, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab33bprovided by RGD
Official Full Name: RAB33B, member RAS oncogene familyprovided by RGD
Primary source: RGD:1308353
See related: EnsemblRapid:ENSRNOG00000013035 AllianceGenome:RGD:1308353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including autophagosome assembly; regulation of Golgi organization; and regulation of vesicle-mediated transport. Is active in presynapse. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia 2. Orthologous to human RAB33B (RAB33B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 87.9), Lung (RPKM 58.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (137678953..137689581)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (135528116..135538719)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (140541619..140552220)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in intra-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of constitutive secretory pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER	ISO Inferred from Sequence Orthology more info
involved_in skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi lumen	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	EXP Inferred from Experiment more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-33B

Names: RAB33B, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.