Opa1 Optic atrophy 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Opa1provided by FlyBase
Official Full Name: Optic atrophy 1provided by FlyBase
Primary source: FLYBASE:FBgn0261276
Locus tag: Dmel_CG8479
See related: AllianceGenome:FB:FBgn0261276
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8479; Dmel\CG8479; dOpa; dOpa1; dOPA1; l(2)s3475; opa1; OPA1; opa1-like; Opa1-like; OPA1-like
Summary: Predicted to enable GTPase activity and microtubule binding activity. Involved in compound eye morphogenesis; mitochondrial fusion; and positive regulation of mitochondrial fusion. Located in mitochondrion. Is expressed in adult head; adult heart; indirect flight muscle cell; and organism. Used to study optic atrophy. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 50E4-50E4; 2-69 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14230611..14235449, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10118116..10122954, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy.
Title: Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy.
The authors propose that Osa and its target genes opa and D form an incoherent feedforward loop (FFL) and a new mechanism allowing the successive expression of temporal identities in intermediate neural progenitors.
Title: The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop.
Depletion of Mitofusin (dMfn) or Opa1 led to dysfunctional mitochondria, activation of Target of rapamycin (TOR) and a marked accumulation of lipid droplets. Enhancement of lipid utilization by the mitochondria attenuated TOR activation and rescued the loss of GSCs that was caused by inhibition of mitochondrial fusion.
Title: Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis.
lack of ChChd3 leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki). Furthermore, loss of ChChd3 induces oxidative stress and activates the JNK pathway. In addition, depletion of other mitochondrial fusion components, Opa1 or Marf, inactivates the Hippo pathway as well.
Title: Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development.
Mitochondrial fusion is regulated spatiotemporally by Ewg through Opa1-like during indirect flight muscles differentiation and growth.
Title: Drosophila Erect wing (Ewg) controls mitochondrial fusion during muscle growth and maintenance by regulation of the Opa1-like gene.
these results suggest that rho-7 and Opa1-like function in a common molecular pathway affecting mitochondrial function and apoptosis in Drosophila melanogaster.
Title: Rhomboid-7 over-expression results in Opa1-like processing and malfunctioning mitochondria.
MARF and Opa1 control mitochondrial and cardiac function in Drosophila.
Title: MARF and Opa1 control mitochondrial and cardiac function in Drosophila.
results suggest that heterozygous mutation of dOpa1 shows organ-specific pathogenesis and is associated with multiple organ abnormalities in an age-dependent and organ-specific manner
Title: Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner.
Alterations in both mitochondrial morphology and ATP production caused by either parkin or PINK1 loss of function could be rescued by the mitochondrial fusion proteins Mfn2 and OPA1 or by a dominant negative mutant of the fission protein Drp1.
Title: Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
Results demonstrate the important role of OPA1 in aging and lifespan, which is most likely mediated through augmented reactive oxygen species production.
Title: Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0786 (e-PCR)
- UniSTS:1532

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISM Inferred from Sequence Model more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: optic atrophy 1

Names: CG8479-PA; CG8479-PB; CG8479-PC; CG8479-PD; CG8479-PE; Opa1-PA; Opa1-PB; Opa1-PC; Opa1-PD; Opa1-PE; Opa1-like; dOpa1; drosophila optic atrophy 1-like; lethal (2) s3475; optic atrophy 1 ortholog; optic atrophy 1-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14230611..14235449 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299483.1 → NP_001286412.1 optic atrophy 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286412.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFB8, E8NH94

Conserved Domains (1) summary

cd08771
Location:259 → 533

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_137097.3 → NP_610941.1 optic atrophy 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610941.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH94, Q95U20

Related

FBpp0086699

Conserved Domains (1) summary

cd08771
Location:259 → 533

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_001299484.1 → NP_001286413.1 optic atrophy 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286413.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LF33

Conserved Domains (1) summary

cd08771
Location:259 → 533

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_001299482.1 → NP_001286411.1 optic atrophy 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286411.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGF5, E8NH94

Conserved Domains (1) summary

cd08771
Location:298 → 572

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_166040.2 → NP_725369.1 optic atrophy 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725369.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9N0, E8NH94

Related

FBpp0086700

Conserved Domains (1) summary

cd08771
Location:298 → 572

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins