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RN-tre Related to the N terminus of tre oncogene [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36554, updated on 9-Dec-2024

Summary

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Official Symbol
RN-treprovided by FlyBase
Official Full Name
Related to the N terminus of tre oncogeneprovided by FlyBase
Primary source
FLYBASE:FBgn0020620
Locus tag
Dmel_CG8085
See related
AllianceGenome:FB:FBgn0020620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13351; CG8085; Dmel\CG8085; DRN-tre
Summary
Predicted to enable GTPase activator activity. Predicted to be located in vesicle. Is expressed in organism. Orthologous to several human genes including USP6NL (USP6 N-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See RN-tre in Genome Data Viewer
Location:
50C23-50C23; 2-68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13984815..13990707, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9872320..9878212, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromosome transmission fidelity 4 Neighboring gene uncharacterized protein Neighboring gene mastermind Neighboring gene mir-4978 stem loop Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and expression analysis of a Drosophila gene product related to the tre oncogene. Yedvobnick B, et al. Biochim Biophys Acta, 1998 Feb 11. PMID 9512660
  2. The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Smoller D, et al. Genes Dev, 1990 Oct. PMID 1701150
  3. The Drosophila melanogaster Rab GAP RN-tre cross-talks with the Rho1 signaling pathway to regulate nonmuscle myosin II localization and function. Platenkamp A, et al. Mol Biol Cell, 2020 Oct 1. PMID 32816624, Free PMC Article
  4. Rab-mediated vesicular transport is required for neuronal positioning in the developing Drosophila visual system. Houalla T, et al. Mol Brain, 2010 Jun 11. PMID 20540751, Free PMC Article
  5. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. Nicolaï M, et al. J Neurobiol, 2003 Dec. PMID 14608664

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_001188925.2
  • related to the N terminus of tre oncogene, isoform E
NP_001260961.1
  • related to the N terminus of tre oncogene, isoform F
NP_523736.1
  • related to the N terminus of tre oncogene, isoform B
NP_652381.1
  • related to the N terminus of tre oncogene, isoform A
NP_725351.1
  • related to the N terminus of tre oncogene, isoform C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13984815..13990707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166028.4 → NP_725351.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725351.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RE0
    Related
    FBpp0086729
    Conserved Domains (1) summary
    smart00164
    Location:100 → 315
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_001274032.2 → NP_001260961.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEQ5
    Conserved Domains (1) summary
    smart00164
    Location:100 → 315
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. NM_001201996.3 → NP_001188925.2  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188925.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD18
    Conserved Domains (1) summary
    smart00164
    Location:100 → 315
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  4. NM_144124.4 → NP_652381.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652381.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9K4
    Related
    FBpp0086731
    Conserved Domains (1) summary
    smart00164
    Location:100 → 315
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  5. NM_079012.5 → NP_523736.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523736.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KQC4
    Related
    FBpp0086730
    Conserved Domains (1) summary
    smart00164
    Location:100 → 315
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD18 A0A0B4JD18
A0A0B4KEQ5 A0A0B4KEQ5
A1Z9K4 A1Z9K4
Q5BI38 Q5BI38
Q7KQC4 Q7KQC4
Q95RE0 Q95RE0

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