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CG8067 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36552, updated on 4-Jan-2025

Summary

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Official Symbol
CG8067provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033891
Locus tag
Dmel_CG8067
See related
AllianceGenome:FB:FBgn0033891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8067
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and larval muscle cell. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 16. Orthologous to human NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG8067 in Genome Data Viewer
Location:
50C23-50C23; 2-68 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13983395..13984893)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9870900..9872398)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromosome transmission fidelity 4 Neighboring gene Related to the N terminus of tre oncogene Neighboring gene mastermind Neighboring gene mir-4978 stem loop Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. Vinci G, et al. PLoS One, 2008 Aug 6. PMID 18682733, Free PMC Article
  2. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
  3. Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Ni JQ, et al. Nat Methods, 2008 Jan. PMID 18084299, Free PMC Article
  4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
  5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in matrix side of mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8067-PA
CG8067-PB
NP_001260960.1
NP_610922.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13983395..13984893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274031.2 → NP_001260960.1  uncharacterized protein Dmel_CG8067, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1S1
    Conserved Domains (2) summary
    TIGR02072
    Location:58 → 296
    BioC; malonyl-acyl carrier protein O-methyltransferase BioC
    pfam08241
    Location:79 → 170
    Methyltransf_11; Methyltransferase domain

  2. NM_137078.4 → NP_610922.1  uncharacterized protein Dmel_CG8067, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610922.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1S1
    Related
    FBpp0086721
    Conserved Domains (2) summary
    TIGR02072
    Location:58 → 296
    BioC; malonyl-acyl carrier protein O-methyltransferase BioC
    pfam08241
    Location:79 → 170
    Methyltransf_11; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1S1 Q7K1S1

Gene LinkOut

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