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Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365352, updated on 27-Nov-2024

Summary

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Symbol
Mical2provided by RGD
Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 2provided by RGD
Primary source
RGD:1311773
See related
EnsemblRapid:ENSRNOG00000016210 EnsemblRapid:ENSRNOG00000079050 AllianceGenome:RGD:1311773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mical-2; Micalcl; RSB-11-77; RGD1311773
Summary
Predicted to enable several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and mitogen-activated protein kinase binding activity. Predicted to be involved in several processes, including actin filament depolymerization; heart looping; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be active in actin filament. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 171.4), Brain (RPKM 152.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mical2 in Genome Data Viewer
Location:
1q33
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (175780441..175965157)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (166345853..166530575)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (177048607..177173729)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 47 Neighboring gene dickkopf WNT signaling pathway inhibitor 3 Neighboring gene parvin, alpha Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Actin stimulates reduction of the MICAL-2 monooxygenase domain. McDonald CA, et al. Biochemistry, 2013 Sep 3. PMID 23927065
  2. Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis. Miura K, et al. Biochem Biophys Res Commun, 2008 Apr 4. PMID 18241670
  3. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Pasterkamp RJ, et al. Mol Cell Neurosci, 2006 Jan. PMID 16230022
  4. Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Lundby A, et al. Nat Commun, 2012 Jun 6. PMID 22673903, Free PMC Article
  5. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Lee BC, et al. Mol Cell, 2013 Aug 8. PMID 23911929, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord.
    Title: MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112586, MGC114239

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables F-actin monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD(P)H oxidase H2O2-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD(P)H oxidase H2O2-forming activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart looping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sulfur oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfur oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfur oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
[F-actin]-monooxygenase MICAL2; F-actin-monooxygenase MICAL2
Names
ERK2-binding testicular protein 1
MICAL C-terminal like
MICAL C-terminal-like protein
[F-actin]-methionine sulfoxide oxidase MICAL2
ebitein-1
mical-cL
molecule interacting with CasL protein 2
protein MICAL-2
protein-methionine sulfoxide oxidase MICAL2
NP_001132980.1
NP_001382794.1
NP_872610.2
XP_063125450.1
XP_063125453.1
XP_063125459.1
XP_063125462.1
XP_063125464.1
XP_063125466.1
XP_063125469.1
XP_063125474.1
XP_063125481.1
XP_063125483.1
XP_063125486.1
XP_063125489.1
XP_063125490.1
XP_063125494.1
XP_063125499.1
XP_063125501.1
XP_063125506.1
XP_063125511.1
XP_063125512.1
XP_063125515.1
XP_063125516.1
XP_063125520.1
XP_063125525.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139508.2 → NP_001132980.1  [F-actin]-monooxygenase MICAL2 isoform 2

    See identical proteins and their annotated locations for NP_001132980.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZXM8, A6I861
    Conserved Domains (3) summary
    cd09439
    Location:754 → 808
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam01494
    Location:87 → 274
    FAD_binding_3; FAD binding domain
    cd21250
    Location:514 → 623
    CH_MICAL2; calponin homology (CH) domain found in molecule interacting with CasL protein 2

  2. NM_001395865.1 → NP_001382794.1  [F-actin]-monooxygenase MICAL2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    D4A1F2, F1LW55, Q498N8, Q4G091, Q80WN5
    Conserved Domains (5) summary
    cd09439
    Location:754 → 808
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    smart00033
    Location:520 → 617
    CH; Calponin homology domain
    PHA03247
    Location:826 → 983
    PHA03247; large tegument protein UL36; Provisional
    cl30692
    Location:87 → 224
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    pfam17380
    Location:1509 → 1673
    DUF5401; Family of unknown function (DUF5401)

  3. NM_182669.2 → NP_872610.2  [F-actin]-monooxygenase MICAL2 isoform 3

    See identical proteins and their annotated locations for NP_872610.2

    Status: PROVISIONAL

    Source sequence(s)
    BC098647
    UniProtKB/TrEMBL
    A6I864
    Related
    ENSRNOP00000039759.5, ENSRNOT00000043017.6
    Conserved Domains (1) summary
    pfam12130
    Location:535 → 673
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    175780441..175965157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269404.1 → XP_063125474.1  F-actin-monooxygenase MICAL2 isoform X4

  2. XM_063269413.1 → XP_063125483.1  F-actin-monooxygenase MICAL2 isoform X6

  3. XM_063269416.1 → XP_063125486.1  F-actin-monooxygenase MICAL2 isoform X7

  4. XM_063269380.1 → XP_063125450.1  F-actin-monooxygenase MICAL2 isoform X1

  5. XM_063269396.1 → XP_063125466.1  F-actin-monooxygenase MICAL2 isoform X2

  6. XM_063269399.1 → XP_063125469.1  F-actin-monooxygenase MICAL2 isoform X3

  7. XM_063269455.1 → XP_063125525.1  F-actin-monooxygenase MICAL2 isoform X15

  8. XM_063269383.1 → XP_063125453.1  F-actin-monooxygenase MICAL2 isoform X1

  9. XM_063269389.1 → XP_063125459.1  F-actin-monooxygenase MICAL2 isoform X1

  10. XM_063269392.1 → XP_063125462.1  F-actin-monooxygenase MICAL2 isoform X1

  11. XM_063269420.1 → XP_063125490.1  F-actin-monooxygenase MICAL2 isoform X9

  12. XM_063269419.1 → XP_063125489.1  F-actin-monooxygenase MICAL2 isoform X8

  13. XM_063269431.1 → XP_063125501.1  F-actin-monooxygenase MICAL2 isoform X10

  14. XM_063269446.1 → XP_063125516.1  F-actin-monooxygenase MICAL2 isoform X13

  15. XM_063269441.1 → XP_063125511.1  F-actin-monooxygenase MICAL2 isoform X12

  16. XM_063269424.1 → XP_063125494.1  F-actin-monooxygenase MICAL2 isoform X9

  17. XM_063269436.1 → XP_063125506.1  F-actin-monooxygenase MICAL2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6AIG9
    Related
    ENSRNOP00000093313.1, ENSRNOT00000102148.2

  18. XM_063269445.1 → XP_063125515.1  F-actin-monooxygenase MICAL2 isoform X12

  19. XM_063269429.1 → XP_063125499.1  F-actin-monooxygenase MICAL2 isoform X9

    Related
    ENSRNOP00000074877.1, ENSRNOT00000081595.3

  20. XM_063269450.1 → XP_063125520.1  F-actin-monooxygenase MICAL2 isoform X14

  21. XM_063269411.1 → XP_063125481.1  F-actin-monooxygenase MICAL2 isoform X5

  22. XM_063269394.1 → XP_063125464.1  F-actin-monooxygenase MICAL2 isoform X1

  23. XM_063269442.1 → XP_063125512.1  F-actin-monooxygenase MICAL2 isoform X12

RNA

  1. XR_010055211.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A1F2.2 GenPept UniProtKB/Swiss-Prot:D4A1F2

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