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Cyb5r2 cytochrome b5 reductase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365345, updated on 27-Nov-2024

Summary

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Official Symbol
Cyb5r2provided by RGD
Official Full Name
cytochrome b5 reductase 2provided by RGD
Primary source
RGD:1308421
See related
EnsemblRapid:ENSRNOG00000019751 AllianceGenome:RGD:1308421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308421
Summary
Predicted to enable FAD binding activity and cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be involved in sterol biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human CYB5R2 (cytochrome b5 reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 58.5), Muscle (RPKM 37.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyb5r2 in Genome Data Viewer
Location:
1q33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (171062083..171076183, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (161655862..161664359, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (171971424..171981586, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485161 Neighboring gene olfactomedin-like 1 Neighboring gene PPFIA binding protein 2 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 like 1 Neighboring gene ovochymase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytochrome b5 reductase: role of the si-face residues, proline 92 and tyrosine 93, in structure and catalysis. Marohnic CC, et al. Biochemistry, 2005 Feb 22. PMID 15709757
  2. NADH-Cytochrome B5 reductase 2 suppresses retinal vascular dysfunction through regulation of vascular endothelial growth factor A in diabetic retinopathy. Chen J, et al. Exp Eye Res, 2022 Sep. PMID 35820466
  3. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Zhu H, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611283, Free PMC Article
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NADH-Cytochrome B5 reductase 2 suppresses retinal vascular dysfunction through regulation of vascular endothelial growth factor A in diabetic retinopathy.
    Title: NADH-Cytochrome B5 reductase 2 suppresses retinal vascular dysfunction through regulation of vascular endothelial growth factor A in diabetic retinopathy.
  2. Changes in the nature of the side-chain constituents in the conserved residues, such as proline-92 and tyrosine-93, exert considerable influence on the flavin prosthetic group and significantly impact cytochrome B5 reductase turnover.
    Title: Cytochrome b5 reductase: role of the si-face residues, proline 92 and tyrosine 93, in structure and catalysis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables cytochrome-b5 reductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH-cytochrome b5 reductase 2
Names
b5R.2
NP_001014266.1
XP_017444972.3
XP_038941094.2
XP_063125410.1
XP_063125411.1
XP_063125420.1
XP_063125422.1
XP_063125426.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014244.1 → NP_001014266.1  NADH-cytochrome b5 reductase 2

    See identical proteins and their annotated locations for NP_001014266.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079235
    UniProtKB/Swiss-Prot
    Q6AY12
    UniProtKB/TrEMBL
    A0A8L2QFU7, A6I7S6
    Related
    ENSRNOP00000100486.1, ENSRNOT00000140793.1
    Conserved Domains (1) summary
    PLN02252
    Location:13 → 276
    PLN02252; nitrate reductase [NADPH]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    171062083..171076183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269356.1 → XP_063125426.1  NADH-cytochrome b5 reductase 2 isoform X2

  2. XM_063269350.1 → XP_063125420.1  NADH-cytochrome b5 reductase 2 isoform X1

  3. XM_063269341.1 → XP_063125411.1  NADH-cytochrome b5 reductase 2 isoform X1

  4. XM_063269352.1 → XP_063125422.1  NADH-cytochrome b5 reductase 2 isoform X2

  5. XM_063269340.1 → XP_063125410.1  NADH-cytochrome b5 reductase 2 isoform X1

    Related
    ENSRNOP00000026744.7, ENSRNOT00000026744.9

  6. XM_017589483.3 → XP_017444972.3  NADH-cytochrome b5 reductase 2 isoform X2

    Related
    ENSRNOP00000108809.1, ENSRNOT00000126833.1

  7. XM_039085166.2 → XP_038941094.2  NADH-cytochrome b5 reductase 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY12.1 GenPept UniProtKB/Swiss-Prot:Q6AY12

Gene LinkOut

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