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Zdhhc13 zinc finger DHHC-type palmitoyltransferase 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365252, updated on 27-Nov-2024

Summary

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Official Symbol
Zdhhc13provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 13provided by RGD
Primary source
RGD:1309736
See related
EnsemblRapid:ENSRNOG00000014277 AllianceGenome:RGD:1309736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable magnesium ion transmembrane transporter activity and protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and protein targeting to membrane. Predicted to be located in Golgi apparatus; Golgi-associated vesicle membrane; and endoplasmic reticulum. Predicted to be active in Golgi membrane. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 109.7), Spleen (RPKM 84.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc13 in Genome Data Viewer
Location:
1q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (107623599..107662178)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (98487319..98525906)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (104106211..104145045)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member B3 like Neighboring gene MAS-related GPR, member B2 Neighboring gene cysteine and glycine rich protein 3 Neighboring gene E2F transcription factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. Goytain A, et al. J Biol Chem, 2008 Nov 28. PMID 18794299, Free PMC Article
  2. The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Lemonidis K, et al. Mol Biol Cell, 2014 Dec 1. PMID 25253725, Free PMC Article
  3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156470

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi-associated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC13
Names
probable palmitoyltransferase ZDHHC13
zinc finger, DHHC domain containing 13
zinc finger, DHHC-type containing 13
NP_001382044.1
XP_038940918.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395115.1 → NP_001382044.1  palmitoyltransferase ZDHHC13

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JBF2, E9PU37
    Related
    ENSRNOP00000019175.4, ENSRNOT00000019175.7
    Conserved Domains (3) summary
    sd00045
    Location:81 → 112
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:423 → 557
    DHHC; DHHC palmitoyltransferase
    cl39094
    Location:66 → 269
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    107623599..107662178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084990.2 → XP_038940918.1  palmitoyltransferase ZDHHC13 isoform X1

    Conserved Domains (3) summary
    COG0666
    Location:15 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:18 → 49
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:293 → 427
    DHHC; DHHC palmitoyltransferase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039037.1: Suppressed sequence

    Description
    NM_001039037.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version

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