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bbc bb in a boxcar [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36496, updated on 9-Dec-2024

Summary

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Official Symbol
bbcprovided by FlyBase
Official Full Name
bb in a boxcarprovided by FlyBase
Primary source
FLYBASE:FBgn0033844
Locus tag
Dmel_CG6016
See related
AllianceGenome:FB:FBgn0033844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bbc; cept; CG6016; dCCS2; Dmel\CG6016; Ept
Summary
Predicted to enable diacylglycerol cholinephosphotransferase activity and ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Located in endoplasmic reticulum. Is expressed in adult head and adult heart. Used to study retinal disease. Orthologous to several human genes including CHPT1 (choline phosphotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See bbc in Genome Data Viewer
Location:
50A11-50A13; 2-68 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13486634..13494862, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9374139..9382367, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene crowded by cid Neighboring gene centromere identifier Neighboring gene downstream of receptor kinase Neighboring gene mars Neighboring gene Myb-interacting protein 120 Neighboring gene mitochondrial translation elongation factor Tu 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. Liu Y, et al. PLoS Genet, 2014 Mar. PMID 24603715, Free PMC Article
  2. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article
  3. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Lim HY, et al. Genes Dev, 2011 Jan 15. PMID 21245170, Free PMC Article
  4. Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. Meltzer S, et al. Cell Rep, 2017 Oct 24. PMID 29069593, Free PMC Article
  5. Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. Midorikawa R, et al. J Neurosci, 2010 Aug 11. PMID 20702701, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables diacylglycerol cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bb in a boxcar
Names
CDP-ethanolamine phosphotransferase
CG6016-PA
CG6016-PB
CG6016-PC
CG6016-PE
bbc-PA
bbc-PB
bbc-PC
bbc-PE
NP_001246300.1
NP_001260955.1
NP_610877.2
NP_725301.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13486634..13494862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259371.2 → NP_001246300.1  bb in a boxcar, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246300.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7Y4, U3GRY8
    Conserved Domains (1) summary
    cl00453
    Location:12 → 328
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  2. NM_165993.3 → NP_725301.1  bb in a boxcar, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725301.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9E0, U3GRY8
    Related
    FBpp0086818
    Conserved Domains (1) summary
    cl00453
    Location:12 → 328
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  3. NM_001274026.1 → NP_001260955.1  bb in a boxcar, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260955.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFL2, U3GRY8
    Conserved Domains (1) summary
    cl00453
    Location:12 → 333
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  4. NM_137033.4 → NP_610877.2  bb in a boxcar, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610877.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9D9, U3GRY8
    Related
    FBpp0086819
    Conserved Domains (1) summary
    cl00453
    Location:12 → 328
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7Y4 A0A0B4K7Y4
A0A0B4KFL2 A0A0B4KFL2
A1Z9D9 A1Z9D9
A1Z9E0 A1Z9E0
Q8T9C6 Q8T9C6

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