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ATP8A ATPase 8A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36488, updated on 9-Dec-2024

Summary

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Official Symbol
ATP8Aprovided by FlyBase
Official Full Name
ATPase 8Aprovided by FlyBase
Primary source
FLYBASE:FBgn0259221
Locus tag
Dmel_CG42321
See related
AllianceGenome:FB:FBgn0259221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.54; Atp8a; CG17034; CG30061; CG42321; DmCG42321; Dmel\CG42321
Old locus tag
Dmel_CG17034; Dmel_CG30061
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including adult head; dorsal sensory complex proper primordium; embryonic hindgut; embryonic large intestine; and ganglia. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4. Orthologous to several human genes including ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ATP8A in Genome Data Viewer
Location:
50A5-50A8; 2-68 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13414978..13439051, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9302483..9326556, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Baramicin A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Isoleucine-AAT 1-3 Neighboring gene transfer RNA:Leucine-CAA 2-1 Neighboring gene transfer RNA:Isoleucine-AAT 1-4 Neighboring gene transfer RNA:Isoleucine-AAT 1-5 Neighboring gene transfer RNA:Isoleucine-AAT 1-6 Neighboring gene transfer RNA:Isoleucine-AAT 1-7 Neighboring gene transfer RNA:Leucine-CAA 1-1 Neighboring gene transfer RNA:Isoleucine-AAT 1-8 Neighboring gene uncharacterized protein Neighboring gene Ser8 Neighboring gene centrosomin Neighboring gene uncharacterized protein Neighboring gene Golgin 97

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila. Sapar ML, et al. Cell Rep, 2018 Aug 28. PMID 30157423, Free PMC Article
  2. Functions of phospholipid flippases. Tanaka K, et al. J Biochem, 2011 Feb. PMID 21134888
  3. The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons. Ji H, et al. Proc Natl Acad Sci U S A, 2023 Jun 13. PMID 37276397, Free PMC Article
  4. Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1. Zhang J, et al. Mol Biol Cell, 2007 Oct. PMID 17671162, Free PMC Article
  5. Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration. Ji H, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35058357, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATPase 8A
Names
ATP8A-PE
ATP8A-PG
ATP8A-PH
ATP8A-PI
ATP8A-PJ
ATP8A-PK
ATP8A-PL
ATP8A-PM
ATP8A-PN
ATP8A-PO
ATP8A-PP
ATP8A-PQ
ATP8A-PR
ATP8A-PS
CG42321-PE
CG42321-PG
CG42321-PH
CG42321-PI
CG42321-PJ
CG42321-PK
CG42321-PL
CG42321-PM
CG42321-PN
CG42321-PO
CG42321-PP
CG42321-PQ
CG42321-PR
CG42321-PS
NP_001137649.1
NP_001137650.1
NP_001137651.1
NP_001137652.1
NP_001137653.1
NP_001137654.1
NP_001137655.1
NP_001137656.1
NP_001188919.1
NP_001246290.1
NP_610873.1
NP_725290.2
NP_725291.2
NP_725292.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13414978..13439051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144182.3 → NP_001137654.1  ATPase 8A, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137654.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z766, Q8T0I4
    Conserved Domains (6) summary
    TIGR01652
    Location:55 → 1073
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:112 → 197
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:471 → 567
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:44 → 106
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:814 → 1066
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:768 → 827
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_137029.4 → NP_610873.1  ATPase 8A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610873.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z766, Q8T0I4
    Related
    FBpp0289032
    Conserved Domains (6) summary
    TIGR01652
    Location:55 → 1073
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:112 → 197
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:471 → 567
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:44 → 106
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:814 → 1066
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:768 → 827
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. NM_001144180.3 → NP_001137652.1  ATPase 8A, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZF7, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:55 → 1073
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:112 → 197
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:471 → 567
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:44 → 106
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:814 → 1066
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:768 → 827
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  4. NM_165984.4 → NP_725290.2  ATPase 8A, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725290.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9C8, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:55 → 1073
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:112 → 197
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:471 → 567
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:44 → 106
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:814 → 1066
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:768 → 827
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  5. NM_001144177.3 → NP_001137649.1  ATPase 8A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137649.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZF5, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:229 → 1247
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:286 → 371
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:645 → 741
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:218 → 280
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:988 → 1240
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:942 → 1001
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  6. NM_001144179.3 → NP_001137651.1  ATPase 8A, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZF8
    Conserved Domains (6) summary
    TIGR01652
    Location:229 → 1247
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:286 → 371
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:645 → 741
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:218 → 280
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:988 → 1240
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:942 → 1001
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  7. NM_170625.4 → NP_725292.2  ATPase 8A, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725292.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZF6, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:180 → 1198
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:237 → 322
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:596 → 692
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:169 → 231
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:939 → 1191
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:893 → 952
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  8. NM_001144183.3 → NP_001137655.1  ATPase 8A, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137655.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZF6, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:180 → 1198
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:237 → 322
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:596 → 692
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:169 → 231
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:939 → 1191
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:893 → 952
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  9. NM_170624.4 → NP_725291.2  ATPase 8A, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725291.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z766, Q0E990
    Conserved Domains (6) summary
    TIGR01652
    Location:180 → 1198
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:237 → 322
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:596 → 692
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:169 → 231
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:939 → 1191
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:893 → 952
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  10. NM_001259361.1 → NP_001246290.1  ATPase 8A, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246290.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7Y0, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:49 → 1067
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:106 → 191
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:465 → 561
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:38 → 100
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:808 → 1060
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:762 → 821
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  11. NM_001144181.3 → NP_001137653.1  ATPase 8A, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZF9, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:55 → 1073
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:112 → 197
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:471 → 567
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:44 → 106
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:814 → 1066
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:768 → 827
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  12. NM_001144184.3 → NP_001137656.1  ATPase 8A, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137656.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZG0, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:229 → 1247
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:286 → 371
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:645 → 741
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:218 → 280
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:988 → 1240
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:942 → 1001
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  13. NM_001144178.3 → NP_001137650.1  ATPase 8A, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137650.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z766, Q6AWM7
    Conserved Domains (6) summary
    TIGR01652
    Location:180 → 1198
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:237 → 322
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:596 → 692
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:169 → 231
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:939 → 1191
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:893 → 952
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  14. NM_001201990.1 → NP_001188919.1  ATPase 8A, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188919.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD16, D0Z766
    Conserved Domains (6) summary
    TIGR01652
    Location:46 → 1064
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:103 → 188
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:462 → 558
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:35 → 97
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:805 → 1057
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:759 → 818
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD16 A0A0B4JD16
A0A0B4K7Y0 A0A0B4K7Y0
A1Z9C8 A1Z9C8
B7YZF5 B7YZF5
B7YZF6 B7YZF6
B7YZF7 B7YZF7
B7YZF8 B7YZF8
B7YZF9 B7YZF9
B7YZG0 B7YZG0
Q0E990 Q0E990
Q6AWM7 Q6AWM7
Q8T0I4 Q8T0I4

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