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CG18278 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36487, updated on 9-Dec-2024

Summary

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Official Symbol
CG18278provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033836
Locus tag
Dmel_CG18278
See related
AllianceGenome:FB:FBgn0033836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG18278
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Predicted to be involved in glycosaminoglycan metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG18278 in Genome Data Viewer
Location:
50A5-50A5; 2-68 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13408042..13409887, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9295547..9297392, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Attacin-C Neighboring gene uncharacterized protein Neighboring gene Baramicin A2 Neighboring gene pseudo Neighboring gene Baramicin A1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium. Huang J, et al. Proc Natl Acad Sci U S A, 2023 Mar 21. PMID 36917667, Free PMC Article
  2. dGLYAT modulates Gadd45-mediated JNK activation and cell invasion. Xu M, et al. Cell Div, 2022 Aug 6. PMID 35933447, Free PMC Article
  3. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. Ou Q, et al. PLoS Biol, 2011 Sep. PMID 21980261, Free PMC Article
  4. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Joos JP, et al. Sci Rep, 2018 Feb 13. PMID 29440697, Free PMC Article
  5. Activating transcription factor 3 regulates immune and metabolic homeostasis. Rynes J, et al. Mol Cell Biol, 2012 Oct. PMID 22851689, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine-6-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycosaminoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG18278-PA
NP_725289.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13408042..13409887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165983.2 → NP_725289.1  uncharacterized protein Dmel_CG18278 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725289.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BIL9, Q86NX7
    Related
    FBpp0086833
    Conserved Domains (2) summary
    COG3119
    Location:24 → 464
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16147
    Location:24 → 467
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BIL9 Q5BIL9

Gene LinkOut

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