Dh31-R Diuretic hormone 31 Receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dh31-Rprovided by FlyBase
Official Full Name: Diuretic hormone 31 Receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0052843
Locus tag: Dmel_CG32843
See related: AllianceGenome:FB:FBgn0052843
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.136; anon-WO0170980.137; CG17043; CG17415; CG32843; DH31; DH31-R; dh31-R1; Dh31-R1; DH31-R1; Dh31r; Dh31R; DH31R; DmeCG32843; Dmel\CG32843
Summary: Enables diuretic hormone receptor activity. Involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including Malpighian tubule Type I cell; central nervous system; glial cell; gut section; and larval MP3 neuron. Human ortholog(s) of this gene implicated in hereditary lymphedema and osteoporosis. Orthologous to human CALCR (calcitonin receptor) and CALCRL (calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13267798..13295927, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9155303..9183432, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

the diuretic hormone 31 receptor (DH31R) mediates body temperature rhythm during the active phase in Drosophila.
Title: Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals.

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Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcitonin receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables diuretic hormone receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG32843-PA; CG32843-PB; CG32843-PC; Calcitonin-like diuretic hormone receptor; DH31 receptor; DH31-receptor; DH[[31]] receptor; Dh31-R-PA; Dh31-R-PB; Dh31-R-PC; diuretic hormone 31 receptor 1

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The following sections contain reference sequences that belong to a specific genome build. Explain