Ranbp9 RAN binding protein 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ranbp9provided by RGD
Official Full Name: RAN binding protein 9provided by RGD
Primary source: RGD:1561940
See related: EnsemblRapid:ENSRNOG00000017951 AllianceGenome:RGD:1561940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RanBPM; RGD1561940
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in cytoskeleton organization and negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol and nuclear body. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RANBP9 (RAN binding protein 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 146.4), Spleen (RPKM 137.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (21426717..21508964)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (21220807..21303009)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (24020874..24103771, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9.
Title: MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9.
RanBPM may modulate TrkB-mediated downstream signaling and biological functions.
Title: RanBPM contributes to TrkB signaling and regulates brain-derived neurotrophic factor-induced neuronal morphogenesis and survival.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Rat102 (e-PCR), detects polymorphism
- UniSTS:226822

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of amyloid precursor protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ran-binding protein 9

Names: ran-binding protein M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427414.1 → NP_001414343.1 ran-binding protein 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I5Y176

Related

ENSRNOP00000077469.1, ENSRNOT00000116992.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

21426717..21508964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276666.1 → XP_063132736.1 ran-binding protein 9 isoform X2
XM_039096249.2 → XP_038952177.1 ran-binding protein 9 isoform X1

UniProtKB/TrEMBL

A0A8I6ACK2

Conserved Domains (4) summary

smart00667
Location:289 → 322

LisH; Lissencephaly type-1-like homology motif

smart00757
Location:540 → 632

CRA; CT11-RanBPM

pfam10607
Location:328 → 382

CLTH; CTLH/CRA C-terminal to LisH motif domain

cl02614
Location:170 → 256

SPRY; SPRY domain