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Mp20 Muscle protein 20 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36468, updated on 9-Dec-2024

Summary

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Official Symbol
Mp20provided by FlyBase
Official Full Name
Muscle protein 20provided by FlyBase
Primary source
FLYBASE:FBgn0002789
Locus tag
Dmel_CG4696
See related
AllianceGenome:FB:FBgn0002789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4696; Dmel\CG4696; Dmmp20; DMMP20; mp20; MP20; Tpn
Summary
Predicted to enable actin filament binding activity. Involved in myoblast fusion and regulation of myoblast fusion. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; border follicle cell; embryonic/larval esophageal visceral muscle; and muscle cell. Orthologous to human TAGLN (transgelin); TAGLN2 (transgelin 2); and TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mp20 in Genome Data Viewer
Location:
49F13-49F13; 2-68 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13246670..13248880)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9134175..9136385)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E14 Neighboring gene long non-coding RNA:CR45278 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the gene for mp20: a Drosophila muscle protein that is not found in asynchronous oscillatory flight muscle. Ayme-Southgate A, et al. J Cell Biol, 1989 Feb. PMID 2537318, Free PMC Article
  2. Testing for asymmetrical gene flow in a Drosophila melanogaster body-size cline. Kennington WJ, et al. Genetics, 2003 Oct. PMID 14573478, Free PMC Article
  3. Differential Expression of Drosophila Transgelins Throughout Development. Vakaloglou KM, et al. Front Cell Dev Biol, 2021. PMID 34322481, Free PMC Article
  4. Nonclinality of molecular variation implicates selection in maintaining a morphological cline of Drosophila melanogaster. Gockel J, et al. Genetics, 2001 May. PMID 11333239, Free PMC Article
  5. High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates. Schlötterer C, et al. Mol Biol Evol, 1998 Oct. PMID 9787433

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
muscle protein 20
Names
CG4696-PA
CG4696-PC
Mp20-PA
Mp20-PC
muscle protein 20 kd
myophilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13246670..13248880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014522.2 → NP_001014522.2  muscle protein 20, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014522.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P14318
    Conserved Domains (3) summary
    COG5199
    Location:7 → 179
    SCP1; Calponin [Cytoskeleton]
    cd00014
    Location:18 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:158 → 178
    Calponin; Calponin family repeat

  2. NM_057295.4 → NP_476643.1  muscle protein 20, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476643.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZF7, P14318, Q1WWC7, Q9V6M7
    Related
    FBpp0086858
    Conserved Domains (3) summary
    COG5199
    Location:7 → 179
    SCP1; Calponin [Cytoskeleton]
    cd00014
    Location:18 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:158 → 178
    Calponin; Calponin family repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14318.2 P14318

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