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Tifab TIFA inhibitor [ Rattus norvegicus (Norway rat) ]

Gene ID: 364674, updated on 9-Dec-2024

Summary

Official Symbol
Tifabprovided by RGD
Official Full Name
TIFA inhibitorprovided by RGD
Primary source
RGD:1311681
See related
EnsemblRapid:ENSRNOG00000011947 AllianceGenome:RGD:1311681
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311681
Summary
Predicted to enable deubiquitinase activator activity. Predicted to be involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to act upstream of with a negative effect on toll-like receptor signaling pathway. Predicted to act upstream of or within several processes, including hemopoiesis; lipopolysaccharide-mediated signaling pathway; and regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. Orthologous to human TIFAB (TIFA inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 70.1), Thymus (RPKM 19.1) and 9 other tissues See more
Orthologs
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Genomic context

See Tifab in Genome Data Viewer
Location:
17p14
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (8438622..8441750)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (8433406..8436541)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9234948..9239266)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547185 Neighboring gene ribosomal protein P1-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene macroH2A.1 histone

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC108845

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables deubiquitinase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in auditory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in craniofacial suture morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
 
involved_in genitalia morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hard palate morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in learned vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in mastication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of relaxation of muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of saliva secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
involved_in peristalsis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of muscle organ development ISO
Inferred from Sequence Orthology
more info
 
involved_in thorax and anterior abdomen determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in trigeminal nerve development ISO
Inferred from Sequence Orthology
more info
 
involved_in vestibulocochlear nerve formation ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TRAF-interacting protein with FHA domain-containing protein B
Names
TIFA inhibitor B
TIFA-like protein
TRAF-interacting protein with forkhead-associated domain, family member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025029.1NP_001020200.1  TRAF-interacting protein with FHA domain-containing protein B

    See identical proteins and their annotated locations for NP_001020200.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091188
    UniProtKB/Swiss-Prot
    Q5BK67
    UniProtKB/TrEMBL
    A6KAN8
    Related
    ENSRNOP00000015878.3, ENSRNOT00000015878.6
    Conserved Domains (1) summary
    pfam00498
    Location:37107
    FHA; FHA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    8438622..8441750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253578.5XP_006253640.1  TRAF-interacting protein with FHA domain-containing protein B isoform X1

    See identical proteins and their annotated locations for XP_006253640.1

    UniProtKB/Swiss-Prot
    Q5BK67
    UniProtKB/TrEMBL
    A6KAN8
    Related
    ENSRNOP00000087435.2, ENSRNOT00000107660.2
    Conserved Domains (1) summary
    pfam00498
    Location:37107
    FHA; FHA domain