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Qsox1 Quiescin sulfhydryl oxidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36464, updated on 9-Dec-2024

Summary

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Official Symbol
Qsox1provided by FlyBase
Official Full Name
Quiescin sulfhydryl oxidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0033814
Locus tag
Dmel_CG4670
See related
AllianceGenome:FB:FBgn0033814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4670; Dmel\CG4670; DmQSOX1; lincRNA.300; qsox1; QSOX1
Summary
Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in protein folding in endoplasmic reticulum. Is active in Golgi apparatus and extracellular space. Is expressed in several structures, including adult head; embryonic anal pad; embryonic large intestine; epithelium; and gut section. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Qsox1 in Genome Data Viewer
Location:
49F11-49F11; 2-68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13231758..13235296, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9119263..9122801, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Peroxin 13 Neighboring gene fates-shifted Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic Mapping and Phenotypic Analysis of GstE14 (E.4.1) on Eye and Antennae Development in Drosophila melanogaster. Thomson L, et al. MicroPubl Biol, 2024. PMID 38681673, Free PMC Article
  2. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Thorpe C, et al. Arch Biochem Biophys, 2002 Sep 1. PMID 12176051
  3. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. Valoskova K, et al. Elife, 2019 Mar 26. PMID 30910009, Free PMC Article
  4. Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. Tien AC, et al. J Cell Biol, 2008 Sep 22. PMID 18809725, Free PMC Article
  5. Pri peptides are mediators of ecdysone for the temporal control of development. Chanut-Delalande H, et al. Nat Cell Biol, 2014 Nov. PMID 25344753

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: c13232823-13232743 mobile_element_type = transposon:INE-1{}5012

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin-dependent sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin-dependent sulfhydryl oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding in endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
quiescin sulfhydryl oxidase 1
Names
CG4670-PA
CG4670-PB
Qsox1-PA
Qsox1-PB
NP_001286383.1
NP_610852.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13231758..13235296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299454.1 → NP_001286383.1  quiescin sulfhydryl oxidase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286383.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQR3
    Conserved Domains (2) summary
    cd02992
    Location:49 → 162
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:430 → 521
    Evr1_Alr; Erv1 / Alr family

  2. NM_137008.3 → NP_610852.1  quiescin sulfhydryl oxidase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610852.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQR3
    Related
    FBpp0086873
    Conserved Domains (2) summary
    cd02992
    Location:49 → 162
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:430 → 521
    Evr1_Alr; Erv1 / Alr family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JQR3 Q7JQR3

Gene LinkOut

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