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Palldl1 palladin-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364558, updated on 9-Dec-2024

Summary

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Symbol
Palldl1provided by RGD
Full Name
palladin-like 1provided by RGD
Primary source
RGD:1359390
See related
EnsemblRapid:ENSRNOG00000082157 AllianceGenome:RGD:1359390
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Palld
Summary
Predicted to be involved in several processes, including actin cytoskeleton organization; cell migration; and nervous system development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 452.0) and Muscle (RPKM 395.5) See more
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Genomic context

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See Palldl1 in Genome Data Viewer
Location:
16p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (32985252..33154619)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (27981315..28143129)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31349140..31390340)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene probable ATP-dependent RNA helicase DDX60 Neighboring gene uncharacterized LOC134482493 Neighboring gene DEXD/H-box helicase 60 Neighboring gene uncharacterized LOC134482494 Neighboring gene uncharacterized LOC120097508

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium. Nicholson L, et al. Reprod Fertil Dev, 2018 Oct. PMID 29739492
  2. CLP36 interacts with palladin in dorsal root ganglion neurons. Hasegawa T, et al. Neurosci Lett, 2010 May 31. PMID 20381583
  3. Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. Salaria SN, et al. Cancer Biol Ther, 2007 Mar. PMID 17404500, Free PMC Article
  4. A critical role for palladin in astrocyte morphology and response to injury. Boukhelifa M, et al. Mol Cell Neurosci, 2003 Aug. PMID 12932445
  5. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. Pogue-Geile KL, et al. PLoS Med, 2006 Dec. PMID 17194196, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two palladin isoforms, 140 kDa and 90 kDa, were analysed, with the migration-associated 140-kDa isoform increasing significantly in rat uterus at the time of implantation when compared with the time of fertilisation.
    Title: Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium.
  2. Palladin is an actin filament regulator at the ectoplasmic specialization.
    Title: Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes.
  3. Actin associated protein palladin is important for the early smooth muscle cell differentiation.
    Title: The actin associated protein palladin is important for the early smooth muscle cell differentiation.
  4. CLP36 may interact with palladin to influence neurite outgrowth during sciatic nerve regeneration.
    Title: CLP36 interacts with palladin in dorsal root ganglion neurons.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palladin
Names
palladin, cytoskeletal associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    32985252..33154619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095179.2 → XP_038951107.2  palladin isoform X3

    UniProtKB/TrEMBL
    Q5M7W2

  2. XM_063275968.1 → XP_063132038.1  palladin isoform X3

    UniProtKB/TrEMBL
    Q5M7W2

  3. XM_039095178.2 → XP_038951106.2  palladin isoform X2

    UniProtKB/TrEMBL
    Q5M7W2

  4. XM_039095177.2 → XP_038951105.2  palladin isoform X1

    UniProtKB/TrEMBL
    Q5M7W2

  5. XM_039095181.2 → XP_038951109.2  palladin isoform X4

    UniProtKB/TrEMBL
    Q5M7W2
    Related
    ENSRNOP00000084755.2, ENSRNOT00000064850.5

  6. XM_063275969.1 → XP_063132039.1  palladin isoform X5

    UniProtKB/TrEMBL
    Q5M7W2

  7. XM_039095182.2 → XP_038951110.2  palladin isoform X4

    UniProtKB/TrEMBL
    Q5M7W2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014237.1: Suppressed sequence

    Description
    NM_001014237.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PALLD (GeneID:23022).
Nucleotide Protein Strain
Heading Accession and Version

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