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Spt-I - Serine palmitoyltransferase subunit I

Predicted to enable serine C-palmitoyltransferase activity. Involved in positive regulation of sphingolipid biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; central brain primordium; embryonic brain; embryonic/larval midgut primordium; and gut section. Used to study hereditary sensory and autonomic neuropathy type 1; hereditary sensory and autonomic neuropathy type 1A; and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A and juvenile amyotrophic lateral sclerosis type 27. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Spt-I

NCBI Orthologs

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Species Gene Architecture aa