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Mdr49 - Multi drug resistance 49

Predicted to enable ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in several processes, including germ cell migration; renal tubular secretion; and response to hypoxia. Predicted to be located in plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in membrane. Is expressed in several structures, including adult head; endoderm anlage; head mesoderm; head mesoderm anlage; and larval brain. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa