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Lfg Lifeguard [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36418, updated on 9-Dec-2024

Summary

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Official Symbol
Lfgprovided by FlyBase
Official Full Name
Lifeguardprovided by FlyBase
Primary source
FLYBASE:FBgn0025692
Locus tag
Dmel_CG3814
See related
AllianceGenome:FB:FBgn0025692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:CK02213; CG3814; CK02213; Dmel\CG3814; LFG
Summary
Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process. Predicted to be active in Golgi apparatus and organelle membrane. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Lfg in Genome Data Viewer
Location:
49D6-49D6; 2-67 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12875164..12876966, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8762669..8764471, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bicaudal Neighboring gene antisense RNA:CR43469 Neighboring gene Beta-alanine transporter Neighboring gene antisense RNA:CR43468 Neighboring gene Aspartyl-tRNA synthetase Neighboring gene N-methyl-D-aspartate receptor-associated protein Neighboring gene antisense RNA:CR45141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Knockdown of the putative Lifeguard homologue CG3814 in neurons of Drosophila melanogaster. M'Angale PG, et al. Genet Mol Res, 2016 Dec 19. PMID 28002605
  2. The Evolutionary Conserved Transmembrane BAX Inhibitor Motif (TMBIM) Containing Protein Family Members 5 and 6 Are Essential for the Development and Survival of Drosophila melanogaster. Zhang L, et al. Front Cell Dev Biol, 2021. PMID 34540824, Free PMC Article
  3. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Rojas-Rivera D, et al. Cell Death Differ, 2012 Jun. PMID 22240901, Free PMC Article
  4. Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging. Kuintzle RC, et al. Nat Commun, 2017 Feb 21. PMID 28221375, Free PMC Article
  5. Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Lee JY, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2009 Nov. PMID 19695344

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in organelle membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
lifeguard
Names
CG3814-PA
CG3814-PB
CG3814-PC
CG3814-PD
Lfg-PA
Lfg-PB
Lfg-PC
Lfg-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12875164..12876966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165955.3 → NP_725236.1  lifeguard, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725236.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8W2
    Related
    FBpp0086926
    Conserved Domains (1) summary
    cd10428
    Location:23 → 240
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

  2. NM_136980.4 → NP_610824.1  lifeguard, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610824.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWP0
    Related
    FBpp0086927
    Conserved Domains (1) summary
    cd10428
    Location:18 → 235
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

  3. NM_001273999.1 → NP_001260928.1  lifeguard, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWP0
    Conserved Domains (1) summary
    cd10428
    Location:18 → 235
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

  4. NM_001273998.1 → NP_001260927.1  lifeguard, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEN6
    Conserved Domains (1) summary
    cd10428
    Location:1 → 199
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEN6 A0A0B4KEN6
Q6AWP0 Q6AWP0
Q8T8W2 Q8T8W2

Gene LinkOut

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