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Nacalpha Nascent polypeptide associated complex protein alpha subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36409, updated on 4-Jan-2025

Summary

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Official Symbol
Nacalphaprovided by FlyBase
Official Full Name
Nascent polypeptide associated complex protein alpha subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0086904
Locus tag
Dmel_CG8759
See related
AllianceGenome:FB:FBgn0086904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aic; alpha-NAC; alphaNAC; CG8759; Dmel\CG8759; l(2)04329; NAC; NAC-alpha; NACalpha; ubNACalpha
Summary
Predicted to enable ribosome binding activity and unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval muscle cell; presumptive embryonic/larval system; and trunk visceral muscle primordium. Orthologous to several human genes including NACA4P (NACA family member 4, pseudogene) and NACA2 (nascent polypeptide associated complex subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Nacalpha in Genome Data Viewer
Location:
49C2-49C3; 2-67 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12759693..12760999, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8647198..8648504, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tafazzin Neighboring gene Diacyl glycerol kinase epsilon Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene oxen Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clusters of temporal discordances reveal distinct embryonic patterning mechanisms in Drosophila and anopheles. Papatsenko D, et al. PLoS Biol, 2011 Jan 25. PMID 21283609, Free PMC Article
  2. 52 Genetic Loci Influencing Myocardial Mass. van der Harst P, et al. J Am Coll Cardiol, 2016 Sep 27. PMID 27659466, Free PMC Article
  3. Localization-dependent oskar protein accumulation; control after the initiation of translation. Braat AK, et al. Dev Cell, 2004 Jul. PMID 15239960
  4. The Drosophila MOS ortholog is not essential for meiosis. Ivanovska I, et al. Curr Biol, 2004 Jan 6. PMID 14711418
  5. Extended disordered regions of ribosome-associated NAC proteins paralogs belong only to the germline in Drosophila melanogaster. Kogan GL, et al. Sci Rep, 2022 Jul 1. PMID 35778515, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
  
part_of nascent polypeptide-associated complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
nascent polypeptide associated complex protein alpha subunit
Names
CG8759-PA
CG8759-PB
CG8759-PC
CG8759-PD
NAC protein alpha subunit
Nacalpha-PA
Nacalpha-PB
Nacalpha-PC
Nacalpha-PD
alpha NAC
lethal (2) 04329
ubiquitous NAC-alpha
ubiquitous NACalpha

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12759693..12760999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057868.4 → NP_477216.1  nascent polypeptide associated complex protein alpha subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477216.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZF1, O16813, Q0E999, Q94518
    UniProtKB/TrEMBL
    A0A0B4LEY6
    Related
    FBpp0086971
    Conserved Domains (3) summary
    COG1308
    Location:74 → 216
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14358
    Location:179 → 215
    UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
    pfam01849
    Location:75 → 128
    NAC; NAC domain

  2. NM_165950.2 → NP_725229.1  nascent polypeptide associated complex protein alpha subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725229.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZF1, O16813, Q0E999, Q94518
    UniProtKB/TrEMBL
    A0A0B4LEY6
    Related
    FBpp0086972
    Conserved Domains (3) summary
    COG1308
    Location:74 → 216
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14358
    Location:179 → 215
    UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
    pfam01849
    Location:75 → 128
    NAC; NAC domain

  3. NM_134312.3 → NP_599139.1  nascent polypeptide associated complex protein alpha subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599139.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZF1, O16813, Q0E999, Q94518
    UniProtKB/TrEMBL
    A0A0B4LEY6
    Related
    FBpp0086973
    Conserved Domains (3) summary
    COG1308
    Location:74 → 216
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14358
    Location:179 → 215
    UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
    pfam01849
    Location:75 → 128
    NAC; NAC domain

  4. NM_001299434.1 → NP_001286363.1  nascent polypeptide associated complex protein alpha subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286363.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZF1, O16813, Q0E999, Q94518
    UniProtKB/TrEMBL
    A0A0B4LEY6
    Conserved Domains (3) summary
    COG1308
    Location:74 → 216
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14358
    Location:179 → 215
    UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
    pfam01849
    Location:75 → 128
    NAC; NAC domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEY6 A0A0B4LEY6
Q94518.2 Q94518

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