Taz - Tafazzin

Enables phosphatidylcholine:cardiolipin O-linoleoyltransferase activity. Involved in cardiolipin acyl-chain remodeling; cardiolipin biosynthetic process; and sperm individualization. Located in Golgi apparatus; endoplasmic reticulum; and mitochondrion. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut primordium; and gut section. Used to study Barth syndrome. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). [provided by Alliance of Genome Resources, Nov 2024]

NCBI Orthologs

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