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Pigc phosphatidylinositol glycan anchor biosynthesis, class C [ Rattus norvegicus (Norway rat) ]

Gene ID: 364032, updated on 4-Jan-2025

Summary

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Official Symbol
Pigcprovided by RGD
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Cprovided by RGD
Primary source
RGD:1311337
See related
EnsemblRapid:ENSRNOG00000026497 AllianceGenome:RGD:1311337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in glycosylphosphatidylinositol biosynthesis defect 16. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 71.9), Spleen (RPKM 65.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pigc in Genome Data Viewer
Location:
13q22
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (76876894..76879420)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (74343619..74346148)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (79886832..79889305)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481576 Neighboring gene uncharacterized LOC103692015 Neighboring gene similar to human chromosome 1 open reading frame 105 Neighboring gene uncharacterized LOC102554129 Neighboring gene dynamin 3 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the phosphatidylinositol glycan C (PIGC) gene are associated with epilepsy and intellectual disability. Edvardson S, et al. J Med Genet, 2017 Mar. PMID 27694521
  2. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Names
PIG-C
phosphatidylinositol glycan, class C
phosphatidylinositol-glycan biosynthesis class C protein
NP_001012207.1
XP_006250244.1
XP_006250245.1
XP_008767887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012207.1 → NP_001012207.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

    See identical proteins and their annotated locations for NP_001012207.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087080
    UniProtKB/Swiss-Prot
    Q5PQQ4
    UniProtKB/TrEMBL
    A6ID87
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

  2. NM_001429830.1 → NP_001416759.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q5PQQ4
    UniProtKB/TrEMBL
    A6ID87

  3. NM_001429831.1 → NP_001416760.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q5PQQ4
    UniProtKB/TrEMBL
    A6ID87

  4. NM_001429832.1 → NP_001416761.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q5PQQ4
    UniProtKB/TrEMBL
    A6ID87

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    76876894..76879420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250182.4 → XP_006250244.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

    Related
    ENSRNOP00000094482.1, ENSRNOT00000105154.2
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

  2. XM_006250183.4 → XP_006250245.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

    Related
    ENSRNOP00000035922.3, ENSRNOT00000035558.6
    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

  3. XM_008769665.4 → XP_008767887.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

    Conserved Domains (1) summary
    pfam06432
    Location:14 → 284
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQQ4.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ4

Gene LinkOut

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