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wuc Wake-up-call [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36401, updated on 9-Dec-2024

Summary

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Official Symbol
wucprovided by FlyBase
Official Full Name
Wake-up-callprovided by FlyBase
Primary source
FLYBASE:FBgn0033770
Locus tag
Dmel_CG12442
See related
AllianceGenome:FB:FBgn0033770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
147114_at; BcDNA:AT27450; CG12442; Dmel\CG12442
Summary
Involved in negative regulation of transcription by RNA polymerase II and spermatogenesis. Located in chromatin. Is active in nucleus. Is expressed in primary spermatocyte and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See wuc in Genome Data Viewer
Location:
49C1-49C1; 2-67 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12700081..12700851)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8587586..8588356)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 49a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mos oncogene Neighboring gene Tafazzin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A transposon expression burst accompanies the activation of Y-chromosome fertility genes during Drosophila spermatogenesis. Lawlor MA, et al. Nat Commun, 2021 Nov 25. PMID 34824217, Free PMC Article
  2. The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila. Lu C, et al. Development, 2013 Sep. PMID 23884444, Free PMC Article
  3. Tissue, cell type and stage-specific ectopic gene expression and RNAi induction in the Drosophila testis. White-Cooper H. Spermatogenesis, 2012 Jan 1. PMID 22553486, Free PMC Article
  4. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
  5. Transcriptional regulation during Drosophila spermatogenesis. Lim C, et al. Spermatogenesis, 2012 Jul 1. PMID 23087835, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wuc represses testis-specific gene expression, and this repression is counteracted by aly.
    Title: Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DRM complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Wake-up-call
Names
CG12442-PA
CG12442-PB
wake-up-call
wuc-PA
wuc-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12700081..12700851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103821.2 → NP_001097291.1  Wake-up-call, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097291.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z949, Q8MZ81
    Conserved Domains (1) summary
    pfam10044
    Location:57 → 127
    LIN52; Retinal tissue protein

  2. NM_136970.3 → NP_610814.1  Wake-up-call, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z949, Q8MZ81
    Related
    FBpp0086962
    Conserved Domains (1) summary
    pfam10044
    Location:57 → 127
    LIN52; Retinal tissue protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z949 A1Z949
Q8MZ81 Q8MZ81

Gene LinkOut

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