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Nckap5 NCK-associated protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363974, updated on 4-Jan-2025

Summary

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Official Symbol
Nckap5provided by RGD
Official Full Name
NCK-associated protein 5provided by RGD
Primary source
RGD:1564507
See related
EnsemblRapid:ENSRNOG00000021553 AllianceGenome:RGD:1564507
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nap5; RGD1564507
Summary
Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be active in microtubule plus-end. Used to study proteinuria. Orthologous to human NCKAP5 (NCK associated protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 216.2), Adrenal (RPKM 35.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nckap5 in Genome Data Viewer
Location:
13q12
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (39922576..40835849, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (37369948..38283257, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (42265875..43049232, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member F5 Neighboring gene G protein-coupled receptor 39 Neighboring gene Ly6/Plaur domain containing 1 Neighboring gene proteasome activator subunit 2, pseudogene 1 Neighboring gene tubulin, alpha 1C, pseudogene 1 Neighboring gene ferritin light chain 1, pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. Moreno C, et al. Am J Physiol Heart Circ Physiol, 2011 Apr. PMID 21257920, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nck-associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    39922576..40835849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599040.3 → XP_017454529.1  nck-associated protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYD4, F1LU96
    Related
    ENSRNOP00000085272.2, ENSRNOT00000105224.2
    Conserved Domains (3) summary
    COG1196
    Location:33 → 252
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:667 → 1053
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1433 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  2. XM_039091169.2 → XP_038947097.1  nck-associated protein 5 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Conserved Domains (3) summary
    COG1196
    Location:33 → 252
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:701 → 1087
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1467 → 1767
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  3. XM_039091162.2 → XP_038947090.1  nck-associated protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYD4, F1LU96
    Related
    ENSRNOP00000084549.2, ENSRNOT00000116447.2
    Conserved Domains (3) summary
    COG1196
    Location:33 → 252
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:667 → 1053
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1433 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  4. XM_063272672.1 → XP_063128742.1  nck-associated protein 5 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZYD4

  5. XM_063272674.1 → XP_063128744.1  nck-associated protein 5 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZYD4

  6. XM_039091163.2 → XP_038947091.1  nck-associated protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Conserved Domains (3) summary
    COG1196
    Location:8 → 227
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:642 → 1028
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1408 → 1708
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  7. XM_063272675.1 → XP_063128745.1  nck-associated protein 5 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Related
    ENSRNOP00000105951.1, ENSRNOT00000167765.1

  8. XM_063272673.1 → XP_063128743.1  nck-associated protein 5 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZYD4

  9. XM_039091166.2 → XP_038947094.1  nck-associated protein 5 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Conserved Domains (3) summary
    COG1196
    Location:8 → 184
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:599 → 985
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1365 → 1665
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  10. XM_039091164.2 → XP_038947092.1  nck-associated protein 5 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Related
    ENSRNOP00000107266.1, ENSRNOT00000125237.1
    Conserved Domains (3) summary
    COG1196
    Location:4 → 211
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:626 → 1012
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1392 → 1692
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  11. XM_063272676.1 → XP_063128746.1  nck-associated protein 5 isoform X11

    UniProtKB/TrEMBL
    A0A8I6A100

  12. XM_017599036.3 → XP_017454525.2  nck-associated protein 5 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Conserved Domains (3) summary
    TIGR02168
    Location:73 → 270
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:619 → 1005
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1385 → 1685
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  13. XM_008769508.4 → XP_008767730.3  nck-associated protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Conserved Domains (3) summary
    TIGR02168
    Location:73 → 291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:683 → 1069
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1449 → 1749
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  14. XM_039091165.2 → XP_038947093.1  nck-associated protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Conserved Domains (3) summary
    TIGR02168
    Location:15 → 233
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:625 → 1011
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1391 → 1691
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  15. XM_039091168.2 → XP_038947096.1  nck-associated protein 5 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZYD4
    Conserved Domains (2) summary
    PHA03247
    Location:551 → 956
    PHA03247; large tegument protein UL36; Provisional
    pfam15246
    Location:1319 → 1619
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  16. XM_017599038.3 → XP_017454527.2  nck-associated protein 5 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A100
    Conserved Domains (3) summary
    TIGR02168
    Location:73 → 291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:683 → 1069
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15246
    Location:1449 → 1749
    NCKAP5; Nck-associated protein 5, Peripheral clock protein
Nucleotide Protein Strain
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