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Sin3A Sin3A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36382, updated on 9-Dec-2024

Summary

Official Symbol
Sin3Aprovided by FlyBase
Official Full Name
Sin3Aprovided by FlyBase
Primary source
FLYBASE:FBgn0022764
Locus tag
Dmel_CG8815
See related
AllianceGenome:FB:FBgn0022764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
159A11T; 27/3; 97/15; CG8815; Dmel\CG8815; dSin3; dSin3A; ES2-3; ESTS:159A11T; EY2-9; l(2)08269; l(2)k02703; l(2)k05415; l(2)k09715; ld; Sin 3A; sin3; Sin3; SIN3; sin3a; sin3A; Sin3a; SIN3A; sni3
Summary
Enables chromatin binding activity and protein heterodimerization activity. Involved in several processes, including determination of adult lifespan; larval somatic muscle development; and regulation of DNA-templated transcription. Located in chromatin; nucleus; and polytene chromosome. Part of Sin3-type complex and transcription repressor complex. Is expressed in organism. Used to study cancer and developmental disorder of mental health. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Sin3A in Genome Data Viewer
Location:
49B5-49B7; 2-67 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12575240..12592917, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8462745..8480422, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 301a1 Neighboring gene Adenylate kinase 6 Neighboring gene stand still Neighboring gene Chloride channel-b Neighboring gene long non-coding RNA:CR30055 Neighboring gene long non-coding RNA:CR45279 Neighboring gene long non-coding RNA:CR43909 Neighboring gene Amphiphysin

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval somatic muscle development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Sin3A
Names
CG8815-PA
CG8815-PB
CG8815-PC
CG8815-PD
CG8815-PE
CG8815-PF
CG8815-PG
CG8815-PH
CG8815-PI
CG8815-PJ
Sin3A-PA
Sin3A-PB
Sin3A-PC
Sin3A-PD
Sin3A-PE
Sin3A-PF
Sin3A-PG
Sin3A-PH
Sin3A-PI
Sin3A-PJ
enhancer of GMR-sina 2-3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12575240..12592917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165916.3NP_725188.1  Sin3A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77025, Q5U0Y0
    Related
    FBpp0087000
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  2. NM_001201984.2NP_001188913.1  Sin3A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z927, O17142
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  3. NM_165915.3NP_725187.1  Sin3A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725187.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77025, Q5U0Y0
    Related
    FBpp0087003
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  4. NM_136955.4NP_610799.2  Sin3A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610799.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z927, O17142
    Related
    FBpp0087001
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  5. NM_001299426.1NP_001286355.1  Sin3A, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF93, O17143
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  6. NM_001316418.1NP_001303347.1  Sin3A, isoform J [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUN9, O17143
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  7. NM_165917.4NP_725189.1  Sin3A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z928, O17143
    Related
    FBpp0087002
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  8. NM_001299425.1NP_001286354.1  Sin3A, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF82, O77025
    Conserved Domains (4) summary
    COG5602
    Location:2381713
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341133
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14961704
    Sin3a_C; C-terminal domain of Sin3a protein
  9. NM_001201983.2NP_001188912.1  Sin3A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188912.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77025, Q5U0Y0
    Conserved Domains (4) summary
    COG5602
    Location:2381715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:14981706
    Sin3a_C; C-terminal domain of Sin3a protein
  10. NM_001259353.2NP_001246282.1  Sin3A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246282.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K765, O77025
    Conserved Domains (4) summary
    COG5602
    Location:2381719
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:10341133
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:15021710
    Sin3a_C; C-terminal domain of Sin3a protein