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Cct6b chaperonin containing TCP1 subunit 6B [ Rattus norvegicus (Norway rat) ]

Gene ID: 363658, updated on 4-Jan-2025

Summary

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Official Symbol
Cct6bprovided by RGD
Official Full Name
chaperonin containing TCP1 subunit 6Bprovided by RGD
Primary source
RGD:1359453
See related
EnsemblRapid:ENSRNOG00000007523 AllianceGenome:RGD:1359453
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561014
Summary
Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytosol. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT6B (chaperonin containing TCP1 subunit 6B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 283.0) and Lung (RPKM 29.6) See more
Orthologs
human mouse all
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Genomic context

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See Cct6b in Genome Data Viewer
Location:
10q26
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68150111..68198932, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67652461..67701385, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70069479..70118194, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095155 Neighboring gene U4 spliceosomal RNA Neighboring gene transcription factor BTF3 homolog 4 pseudogene Neighboring gene uncharacterized LOC102547954 Neighboring gene zinc finger protein 830 Neighboring gene DNA ligase 3 Neighboring gene ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture. Yi X, et al. J Orthop Surg Res, 2019 May 9. PMID 31072365, Free PMC Article
  2. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. Kubota H, et al. FEBS Lett, 1997 Jan 27. PMID 9013858
  3. Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis. Hynes G, et al. FEBS Lett, 1995 Jan 23. PMID 7828721
  4. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
  5. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCT6b overexpression significantly inhibited fibroblasts functions in a model of joint contracture.
    Title: Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-complex protein 1 subunit zeta-2
Names
chaperonin containing Tcp1, subunit 6B (zeta 2)
chaperonin subunit 6b (zeta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014228.1 → NP_001014250.1  T-complex protein 1 subunit zeta-2

    See identical proteins and their annotated locations for NP_001014250.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079020
    UniProtKB/TrEMBL
    F1M2D2, Q6AYJ7
    Related
    ENSRNOP00000009944.6, ENSRNOT00000009944.8
    Conserved Domains (1) summary
    TIGR02347
    Location:3 → 530
    chap_CCT_zeta; T-complex protein 1, zeta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    68150111..68198932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269529.1 → XP_063125599.1  T-complex protein 1 subunit zeta-2 isoform X1

  2. XM_039086489.2 → XP_038942417.1  T-complex protein 1 subunit zeta-2 isoform X3

    Conserved Domains (1) summary
    TIGR02347
    Location:1 → 310
    chap_CCT_zeta; T-complex protein 1, zeta subunit

  3. XM_063269531.1 → XP_063125601.1  T-complex protein 1 subunit zeta-2 isoform X2

  4. XM_063269527.1 → XP_063125597.1  T-complex protein 1 subunit zeta-2 isoform X1

  5. XM_063269530.1 → XP_063125600.1  T-complex protein 1 subunit zeta-2 isoform X1

  6. XM_063269528.1 → XP_063125598.1  T-complex protein 1 subunit zeta-2 isoform X1

  7. XM_063269532.1 → XP_063125602.1  T-complex protein 1 subunit zeta-2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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