Fbll1 fibrillarin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbll1provided by RGD
Official Full Name: fibrillarin-like 1provided by RGD
Primary source: RGD:1562841
See related: EnsemblRapid:ENSRNOG00000015303 AllianceGenome:RGD:1562841
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562841
Summary: Predicted to enable RNA binding activity; histone H2AQ104 methyltransferase activity; and rRNA methyltransferase activity. Predicted to be involved in box C/D sno(s)RNA 3'-end processing and rRNA methylation. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Predicted to be active in Cajal body and nucleolus. Orthologous to human FBLL1 (fibrillarin like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (20762716..20764359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (20258656..20260299, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (20620957..20622600, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AQ104 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst hatching	ISO Inferred from Sequence Orthology more info
involved_in box C/D sno(s)RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
part_of box C/D methylation guide snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1

NP_001102294.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108824.1 → NP_001102294.1 rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HDI9, D3ZVA5

Related

ENSRNOP00000020554.6, ENSRNOT00000020554.9

Conserved Domains (1) summary

PTZ00146
Location:81 → 321

PTZ00146; fibrillarin; Provisional