Septin12 septin 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Septin12provided by RGD
Official Full Name: septin 12provided by RGD
Primary source: RGD:1565511
See related: EnsemblRapid:ENSRNOG00000003137 AllianceGenome:RGD:1565511
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sept12
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; flagellated sperm motility; and protein localization. Predicted to be located in several cellular components, including midbody; perinuclear region of cytoplasm; and sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in spermatogenic failure 10. Orthologous to human SEPTIN12 (septin 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 168.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (11087354..11097036)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (10580900..10590582)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (10774702..10784276)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study describes Sept12, a novel septin, identified in a yeast two hybrid screen using Sept5 as the bait; Sept12 protein levels rise upon sexual maturity and the Sept12 protein colocalizes with the annulus in isolated mature spermatozoa.
Title: Sept12 is a component of the mammalian sperm tail annulus.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	ISO Inferred from Sequence Orthology more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm annulus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: septin-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100865.1 → NP_001094335.1 septin-12

See identical proteins and their annotated locations for NP_001094335.1

Status: PROVISIONAL

Source sequence(s)

BC097401

UniProtKB/Swiss-Prot

Q4V8G5

UniProtKB/TrEMBL

A6K4P8

Related

ENSRNOP00000057921.1, ENSRNOT00000061208.4

Conserved Domains (1) summary

cd01850
Location:45 → 315

CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

11087354..11097036

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086448.2 → XP_038942376.1 septin-12 isoform X3

UniProtKB/TrEMBL

A0A8I6A6R7, A6K4P9

Related

ENSRNOP00000088547.1, ENSRNOT00000111695.2

Conserved Domains (1) summary

cd01850
Location:45 → 272

CDC_Septin; CDC/Septin GTPase family
XM_039086446.2 → XP_038942374.1 septin-12 isoform X1

Conserved Domains (1) summary

cd01850
Location:45 → 272

CDC_Septin; CDC/Septin GTPase family
XM_039086447.2 → XP_038942375.1 septin-12 isoform X2

Conserved Domains (1) summary

cd01850
Location:45 → 272

CDC_Septin; CDC/Septin GTPase family