Abcd1 ATP binding cassette subfamily D member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcd1provided by RGD
Official Full Name: ATP binding cassette subfamily D member 1provided by RGD
Primary source: RGD:1562128
See related: EnsemblRapid:ENSRNOG00000056524 AllianceGenome:RGD:1562128
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALDP; RGD1562128
Summary: Enables ATP binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in very long-chain fatty acid catabolic process. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 109.6), Heart (RPKM 87.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (156579669..156601448)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (151428334..151450115)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (157073860..157095652, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCD1 and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane
Title: Peroxisomal ATP-binding cassette transporters form mainly tetramers.
Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).
Title: Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:376683 (e-PCR)
- UniSTS:157059

UniSTS:238038 (e-PCR)
- UniSTS:238038

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type fatty-acyl-CoA transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type fatty-acyl-CoA transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid elongation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty-acyl-CoA transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty acid import into peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into peroxisome	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into peroxisome	ISS Inferred from Sequence or Structural Similarity more info
involved_in myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in sterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in very long-chain fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty-acyl-CoA catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family D member 1

Names: ATP-binding cassette, sub-family D (ALD), member 1; ATP-binding cassette, subfamily D (ALD), member 1; adrenoleukodystrophy protein

NP_001102291.1

EC 7.6.2.4

XP_038955840.1

EC 7.6.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108821.1 → NP_001102291.1 ATP-binding cassette sub-family D member 1

See identical proteins and their annotated locations for NP_001102291.1

Status: PROVISIONAL

Source sequence(s)

CH474099

UniProtKB/Swiss-Prot

D3ZHR2

UniProtKB/TrEMBL

A0A8I5ZWT6

Related

ENSRNOP00000111558.1, ENSRNOT00000131953.1

Conserved Domains (1) summary

TIGR00954
Location:1 → 682

3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

156579669..156601448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099912.2 → XP_038955840.1 ATP-binding cassette sub-family D member 1 isoform X1

Conserved Domains (1) summary

TIGR00954
Location:95 → 483

3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein