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CG17739 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36333, updated on 9-Dec-2024

Summary

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Official Symbol
CG17739provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033710
Locus tag
Dmel_CG17739
See related
AllianceGenome:FB:FBgn0033710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.35; CT39321; Dmel\CG17739
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell adhesion. Predicted to be active in extracellular matrix. Is expressed in eye and photoreceptor neurons. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG17739 in Genome Data Viewer
Location:
48F6-48F7; 2-66 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12306528..12310412)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8194033..8197917)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene salto Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence that human genes of modular proteins have retained significantly more ancestral introns than their fly or worm orthologues. Bányai L, et al. FEBS Lett, 2004 May 7. PMID 15135065
  2. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article
  3. A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. Xu H, et al. EMBO J, 2004 Feb 25. PMID 14963491, Free PMC Article
  4. A single-cell atlas reveals unanticipated cell type complexity in Drosophila ovaries. Slaidina M, et al. Genome Res, 2021 Oct. PMID 34389661, Free PMC Article
  5. A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi. Fisher WW, et al. Genetics, 2023 Apr 6. PMID 36652461, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17739-PA
Fat-spondin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12306528..12310412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136913.3 → NP_610757.1  uncharacterized protein Dmel_CG17739 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610757.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3Y9
    Related
    FBpp0087006
    Conserved Domains (5) summary
    smart00209
    Location:490 → 541
    TSP1; Thrombospondin type 1 repeats
    cd08544
    Location:23 → 163
    Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
    pfam00090
    Location:815 → 862
    TSP_1; Thrombospondin type 1 domain
    pfam06468
    Location:186 → 373
    Spond_N; Spondin_N
    cl00101
    Location:661 → 715
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3Y9 Q7K3Y9

Gene LinkOut

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