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Traf3ip1 TRAF3 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363286, updated on 4-Jan-2025

Summary

Official Symbol
Traf3ip1provided by RGD
Official Full Name
TRAF3 interacting protein 1provided by RGD
Primary source
RGD:1309252
See related
EnsemblRapid:ENSRNOG00000024468 AllianceGenome:RGD:1309252
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MIP-T3
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cilium organization; negative regulation of macromolecule metabolic process; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and post-anal tail morphogenesis. Predicted to be located in several cellular components, including centrosome; ciliary base; and ciliary tip. Predicted to be part of intraciliary transport particle B. Predicted to be active in axoneme and ciliary basal body. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 60.6), Kidney (RPKM 48.7) and 9 other tissues See more
Orthologs
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Genomic context

See Traf3ip1 in Genome Data Viewer
Location:
9q36
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99521176..99557966)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (92073622..92110427)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98621499..98658223)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480412 Neighboring gene period circadian regulator 2 Neighboring gene uncharacterized LOC134480413 Neighboring gene U6 spliceosomal RNA Neighboring gene ankyrin repeat and SOCS box-containing 1 Neighboring gene uncharacterized LOC134480414

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in morphogenesis of a polarized epithelium IEA
Inferred from Electronic Annotation
more info
 
involved_in morphogenesis of a polarized epithelium ISO
Inferred from Sequence Orthology
more info
 
involved_in morphogenesis of a polarized epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube patterning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary base IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary base ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ciliary tip IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary tip ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary tip ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ciliary transition zone IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary transition zone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of intraciliary transport particle B IEA
Inferred from Electronic Annotation
more info
 
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
 
part_of intraciliary transport particle B ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
TRAF3-interacting protein 1
Names
TNF receptor-associated factor 3 interacting protein 1
intraflagellar transport protein 54 homolog
microtubule-interacting protein associated with TRAF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012204.1NP_001012204.1  TRAF3-interacting protein 1

    See identical proteins and their annotated locations for NP_001012204.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083645
    UniProtKB/Swiss-Prot
    Q5XIN3
    UniProtKB/TrEMBL
    A0A8I5ZJ93
    Related
    ENSRNOP00000076695.2, ENSRNOT00000104108.2
    Conserved Domains (2) summary
    PTZ00438
    Location:151208
    PTZ00438; gamete antigen 27/25-like protein; Provisional
    pfam10243
    Location:49647
    MIP-T3; Microtubule-binding protein MIP-T3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    99521176..99557966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245437.5XP_006245499.2  TRAF3-interacting protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y0E3, A0A8I5ZJ93
    Conserved Domains (2) summary
    PTZ00438
    Location:151208
    PTZ00438; gamete antigen 27/25-like protein; Provisional
    pfam10243
    Location:49618
    MIP-T3; Microtubule-binding protein MIP-T3
  2. XM_017596540.3XP_017452029.1  TRAF3-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWM5, A0A8I5ZJ93
    Related
    ENSRNOP00000069939.1, ENSRNOT00000081992.3
  3. XM_006245435.5XP_006245497.2  TRAF3-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZJ93, A0A8I5ZYG8
    Related
    ENSRNOP00000085077.1, ENSRNOT00000100401.2
    Conserved Domains (2) summary
    PTZ00438
    Location:151208
    PTZ00438; gamete antigen 27/25-like protein; Provisional
    pfam10243
    Location:49615
    MIP-T3; Microtubule-binding protein MIP-T3
  4. XM_006245436.5XP_006245498.2  TRAF3-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZJ93
    Related
    ENSRNOP00000076805.2, ENSRNOT00000113396.2
    Conserved Domains (2) summary
    PTZ00438
    Location:151208
    PTZ00438; gamete antigen 27/25-like protein; Provisional
    pfam10243
    Location:49594
    MIP-T3; Microtubule-binding protein MIP-T3
  5. XM_039083925.2XP_038939853.1  TRAF3-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    pfam17749
    Location:226380
    MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region