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Csrnp1 cysteine and serine rich nuclear protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363165, updated on 4-Jan-2025

Summary

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Official Symbol
Csrnp1provided by RGD
Official Full Name
cysteine and serine rich nuclear protein 1provided by RGD
Primary source
RGD:1305999
See related
EnsemblRapid:ENSRNOG00000033433 AllianceGenome:RGD:1305999
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Axud1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including face morphogenesis; platelet-derived growth factor receptor signaling pathway; and roof of mouth development. Predicted to be active in nucleus. Orthologous to human CSRNP1 (cysteine and serine rich nuclear protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 90.0), Spleen (RPKM 37.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csrnp1 in Genome Data Viewer
Location:
8q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128582364..128594163, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119704712..119717767, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128659883..128673339, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene atherin-like Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene tetratricopeptide repeat domain 21A Neighboring gene uncharacterized LOC108351801 Neighboring gene uncharacterized LOC120094294 Neighboring gene xin actin-binding repeat containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling. Ye X, et al. Exp Cell Res, 2017 Oct 15. PMID 28830684
  2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
  3. PDGF signaling specificity is mediated through multiple immediate early genes. Schmahl J, et al. Nat Genet, 2007 Jan. PMID 17143286
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Axud1 mediated stress-induced cardiomyocytes apoptosis through activating Wnt/beta-catenin signaling pathway.
    Title: Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within face morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine/serine-rich nuclear protein 1
Names
AXIN1 up-regulated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108786.1 → NP_001102256.1  cysteine/serine-rich nuclear protein 1

    See identical proteins and their annotated locations for NP_001102256.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A0A0G2K1S7, A6I3Y5, D4AAK3
    Related
    ENSRNOP00000045373.3, ENSRNOT00000050543.5
    Conserved Domains (1) summary
    pfam16019
    Location:77 → 300
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128582364..128594163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244120.5 → XP_006244182.1  cysteine/serine-rich nuclear protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006244182.1

    UniProtKB/TrEMBL
    A0A0G2K1S7, A6I3Y5, D4AAK3
    Conserved Domains (1) summary
    pfam16019
    Location:77 → 300
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  2. XM_006244121.4 → XP_006244183.1  cysteine/serine-rich nuclear protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006244183.1

    UniProtKB/TrEMBL
    A0A0G2K1S7, A6I3Y5, D4AAK3
    Conserved Domains (1) summary
    pfam16019
    Location:77 → 300
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  3. XM_039081812.2 → XP_038937740.1  cysteine/serine-rich nuclear protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K1S7
    Conserved Domains (1) summary
    pfam16019
    Location:169 → 392
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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