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Tipin timeless interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 363076, updated on 9-Dec-2024

Summary

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Official Symbol
Tipinprovided by RGD
Official Full Name
timeless interacting proteinprovided by RGD
Primary source
RGD:1564084
See related
EnsemblRapid:ENSRNOG00000043068 AllianceGenome:RGD:1564084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UV98; RGD1564084
Summary
The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
Expression
Biased expression in Thymus (RPKM 124.7), Spleen (RPKM 98.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tipin in Genome Data Viewer
Location:
8q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73676020..73696620)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64780813..64801358)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69753363..69768640)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene mitogen activated protein kinase kinase 1 Neighboring gene uncharacterized LOC134480193 Neighboring gene transfer RNA serine (anticodon AGA) 48 Neighboring gene small Cajal body-specific RNA 14 Neighboring gene DIS3-like exosome 3'-5' exoribonuclease Neighboring gene multiple EGF-like-domains 11 Neighboring gene uncharacterized LOC134480194

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. Yoshizawa-Sugata N, et al. J Biol Chem, 2007 Jan 26. PMID 17102137
  2. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. Gotter AL. J Mol Biol, 2003 Aug 1. PMID 12875843
  3. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. Gotter AL, et al. J Mol Biol, 2007 Feb 9. PMID 17141802, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114381

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in cell cycle phase transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TIMELESS-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025287.2 → NP_001020458.1  TIMELESS-interacting protein

    See identical proteins and their annotated locations for NP_001020458.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q4QR88
    UniProtKB/TrEMBL
    A6J5B9, F1LM96
    Related
    ENSRNOP00000059833.4, ENSRNOT00000066973.5
    Conserved Domains (1) summary
    pfam07962
    Location:63 → 145
    Swi3; Replication Fork Protection Component Swi3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    73676020..73696620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265765.1 → XP_063121835.1  TIMELESS-interacting protein isoform X4

  2. XM_063265763.1 → XP_063121833.1  TIMELESS-interacting protein isoform X3

  3. XM_039081743.2 → XP_038937671.1  TIMELESS-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0L4, F1LM96
    Related
    ENSRNOP00000100210.1, ENSRNOT00000166332.1
    Conserved Domains (1) summary
    pfam07962
    Location:116 → 198
    Swi3; Replication Fork Protection Component Swi3

  4. XM_063265762.1 → XP_063121832.1  TIMELESS-interacting protein isoform X2

    UniProtKB/TrEMBL
    F1LM96
    Related
    ENSRNOP00000083756.2, ENSRNOT00000112754.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QR88.1 GenPept UniProtKB/Swiss-Prot:Q4QR88

Gene LinkOut

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