Rnd1 Rho family GTPase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnd1provided by RGD
Official Full Name: Rho family GTPase 1provided by RGD
Primary source: RGD:1306338
See related: EnsemblRapid:ENSRNOG00000059857 AllianceGenome:RGD:1306338
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; neuron remodeling; and regulation of actin cytoskeleton organization. Predicted to be located in actin cytoskeleton; adherens junction; and intracellular membrane-bounded organelle. Predicted to be active in cytosol and plasma membrane. Orthologous to human RND1 (Rho family GTPase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 96.3), Lung (RPKM 33.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (131700321..131707392, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (129821311..129828385, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140349138..140356209, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rnd1 as a novel stretch-sensitive gene which influences cell proliferation and cellular hypertrophy.
Title: Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy.
STI1 participates in Rnd1-induced signal transduction pathways that are involved in the dynamics of the actin cytoskeleton.
Title: STI1 antagonizes cytoskeleton collapse mediated by small GTPase Rnd1 and regulates neurite growth.
SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization.
Title: Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10.
The RND1 mRNA levels increased significantly was expressed in nonpregnant rat myometrium.
Title: Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria.
Our findings demonstrate that Rnd1 is involved in signaling pathways of neuronal activity-dependent dendritic development.
Title: Small GTPase Rnd1 is involved in neuronal activity-dependent dendritic development in hippocampal neurons.
The activity of Rnd1, regulated through FRS2beta, plays an important role in the fibroblast growth factor signaling during neurite outgrowth.
Title: Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.
The RND2 mRNA levels increased significantly was expressed in nonpregnant rat myometrium.
Title: Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria.
investigated the effect of Rnd1 on neuronal morphology; Rnd1 protein was localized in synaptosomal membrane fraction, and plays a role in dendritic spine formation in the developmental synaptogenic stage.
Title: A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE119113 (e-PCR)
- UniSTS:249098

RH141940 (e-PCR)
- UniSTS:223931

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho-related GTP-binding protein Rho6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.