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Elk3 ETS transcription factor ELK3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362871, updated on 2-Nov-2024

Summary

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Official Symbol
Elk3provided by RGD
Official Full Name
ETS transcription factor ELK3provided by RGD
Primary source
RGD:1307764
See related
EnsemblRapid:ENSRNOG00000004367 AllianceGenome:RGD:1307764
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within angiogenesis; regulation of DNA-templated transcription; and wound healing. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ELK3 (ETS transcription factor ELK3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 206.4), Heart (RPKM 123.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elk3 in Genome Data Viewer
Location:
7q13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (29655676..29718163, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (27768582..27831088, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34086213..34149601, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093552 Neighboring gene cilia and flagella associated protein 54 Neighboring gene uncharacterized LOC134479658 Neighboring gene cyclin-dependent kinase 17 Neighboring gene uncharacterized LOC102548950 Neighboring gene uncharacterized LOC134479659

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The transcription factor Net regulates the angiogenic switch. Zheng H, et al. Genes Dev, 2003 Sep 15. PMID 12975317, Free PMC Article
  2. Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor. Yamazaki Y, et al. J Biol Chem, 2003 Aug 15. PMID 12788937
  3. The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage. Kerr N, et al. Mol Cell Neurosci, 2010 Jun. PMID 20304071, Free PMC Article
  4. Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. Gupta M, et al. J Biol Chem, 2003 Nov 7. PMID 12933792
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables purine-rich negative regulatory element binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ETS domain-containing protein Elk-3
Names
ELK3, ETS transcription factor
ELK3, ETS-domain protein
ELK3, member of ETS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108743.1 → NP_001102213.1  ETS domain-containing protein Elk-3

    See identical proteins and their annotated locations for NP_001102213.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473960
    UniProtKB/TrEMBL
    A0A8I6AFZ2, A6IFX9, D4A9V6
    Related
    ENSRNOP00000005911.5, ENSRNOT00000005911.8
    Conserved Domains (1) summary
    smart00413
    Location:5 → 89
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    29655676..29718163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241265.5 → XP_006241327.1  ETS domain-containing protein Elk-3 isoform X1

    See identical proteins and their annotated locations for XP_006241327.1

    UniProtKB/TrEMBL
    A0A8I6AFZ2, A6IFX9, D4A9V6
    Conserved Domains (1) summary
    smart00413
    Location:5 → 89
    ETS; erythroblast transformation specific domain

  2. XM_063263770.1 → XP_063119840.1  ETS domain-containing protein Elk-3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ADA1, A6IFY0

  3. XM_063263769.1 → XP_063119839.1  ETS domain-containing protein Elk-3 isoform X2

  4. XM_063263771.1 → XP_063119841.1  ETS domain-containing protein Elk-3 isoform X4

    UniProtKB/TrEMBL
    A6IFY1
Nucleotide Protein Strain
Heading Accession and Version

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