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Slc41a2 solute carrier family 41 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362861, updated on 27-Nov-2024

Summary

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Official Symbol
Slc41a2provided by RGD
Official Full Name
solute carrier family 41 member 2provided by RGD
Primary source
RGD:1307292
See related
EnsemblRapid:ENSRNOG00000008713 AllianceGenome:RGD:1307292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable inorganic cation transmembrane transporter activity. Predicted to be involved in metal ion transport. Predicted to act upstream of or within metal ion transport and transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human SLC41A2 (solute carrier family 41 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 377.6), Testes (RPKM 57.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc41a2 in Genome Data Viewer
Location:
7q13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22271298..22378764)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20383714..20491178)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26522314..26607861)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S8-like Neighboring gene NOP protein chaperone 1 Neighboring gene uncharacterized LOC102550067 Neighboring gene uncharacterized LOC134479650 Neighboring gene uncharacterized LOC120093545 Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional characterization of the mouse [corrected] solute carrier, SLC41A2. Goytain A, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809054
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inorganic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cobalt ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in iron ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in manganese ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metal ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in nickel cation transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 41 member 2
Names
solute carrier family 41 (magnesium transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108742.2 → NP_001102212.1  solute carrier family 41 member 2 isoform 2

    See identical proteins and their annotated locations for NP_001102212.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6IFH1
    Related
    ENSRNOP00000011572.8, ENSRNOT00000011572.8
    Conserved Domains (1) summary
    pfam01769
    Location:389 → 529
    MgtE; Divalent cation transporter

  2. NM_001401081.1 → NP_001388010.1  solute carrier family 41 member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D4A7D4

  3. NM_001401082.1 → NP_001388011.1  solute carrier family 41 member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D4A7D4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    22271298..22378764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263757.1 → XP_063119827.1  solute carrier family 41 member 2 isoform X2

  2. XM_063263758.1 → XP_063119828.1  solute carrier family 41 member 2 isoform X2

    Related
    ENSRNOP00000102475.1, ENSRNOT00000130064.1

  3. XM_039079426.2 → XP_038935354.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/TrEMBL
    D4A7D4
    Conserved Domains (1) summary
    pfam01769
    Location:413 → 554
    MgtE; Divalent cation transporter

  4. XM_039079423.2 → XP_038935351.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/TrEMBL
    D4A7D4
    Conserved Domains (1) summary
    pfam01769
    Location:413 → 554
    MgtE; Divalent cation transporter

  5. XM_039079428.2 → XP_038935356.1  solute carrier family 41 member 2 isoform X2

    Conserved Domains (1) summary
    pfam01769
    Location:199 → 331
    MgtE; Divalent cation transporter

  6. XM_039079427.2 → XP_038935355.1  solute carrier family 41 member 2 isoform X3

    Related
    ENSRNOP00000108613.1, ENSRNOT00000167280.1
    Conserved Domains (1) summary
    pfam01769
    Location:199 → 331
    MgtE; Divalent cation transporter

  7. XM_039079422.2 → XP_038935350.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/TrEMBL
    D4A7D4
    Related
    ENSRNOP00000099487.1, ENSRNOT00000138998.1
    Conserved Domains (1) summary
    pfam01769
    Location:413 → 554
    MgtE; Divalent cation transporter
Nucleotide Protein Strain
Heading Accession and Version

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