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RnrS Ribonucleoside diphosphate reductase small subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36280, updated on 9-Dec-2024

Summary

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Official Symbol
RnrSprovided by FlyBase
Official Full Name
Ribonucleoside diphosphate reductase small subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0011704
Locus tag
Dmel_CG8975
See related
AllianceGenome:FB:FBgn0011704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.148; CG8975; Dmel\CG8975; DmRNR2; dRNR2; R2; RNR-S; rnr2; Rnr2; RNR2; rnrS; Rnrs; RnRs; RNrS; RNRS
Summary
Enables cysteine-type endopeptidase activator activity involved in apoptotic process. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; head epidermis primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; mitochondrial DNA depletion syndrome 8b; and pancreatic cancer. Orthologous to several human genes including RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See RnrS in Genome Data Viewer
Location:
48D5-48D5; 2-65 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11983145..11985393, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7870650..7872898, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beta1,3-galactosyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene rhomboid-7 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemical Embryology Redux: Metabolic Control of Development. Song Y, et al. Trends Genet, 2020 Aug. PMID 32532533, Free PMC Article
  2. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Duronio RJ, et al. Genes Dev, 1995 Jun 15. PMID 7601349
  3. Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Follette PJ, et al. Curr Biol, 1998 Feb 12. PMID 9501987, Free PMC Article
  4. Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Duronio RJ, et al. Genes Dev, 1995 Jun 15. PMID 7601350
  5. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Royzman I, et al. Genes Dev, 1997 Aug 1. PMID 9271122, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deoxyribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoside-diphosphate reductase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribonucleoside diphosphate reductase small subunit
Names
CG8975-PA
RnrS-PA
ribonucleoside-diphosphate reductase small subunit
ribonucleotide reductase
ribonucleotide reductase small subunit
NP_525111.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11983145..11985393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080372.4 → NP_525111.1  ribonucleoside diphosphate reductase small subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48592, Q9V640
    Related
    FBpp0087152
    Conserved Domains (1) summary
    cl00264
    Location:74 → 393
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48592.2 P48592

Gene LinkOut

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