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Siva1 SIVA1, apoptosis-inducing factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 362791, updated on 4-Jan-2025

Summary

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Official Symbol
Siva1provided by RGD
Official Full Name
SIVA1, apoptosis-inducing factorprovided by RGD
Primary source
RGD:1561872
See related
EnsemblRapid:ENSRNOG00000028640 AllianceGenome:RGD:1561872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siva
Summary
Predicted to enable tumor necrosis factor receptor superfamily binding activity; virus receptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; apoptotic signaling pathway; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human SIVA1 (SIVA1 apoptosis inducing factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 87.5), Spleen (RPKM 70.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Siva1 in Genome Data Viewer
Location:
6q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137526416..137530790)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131705323..131709697)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137209999..137214379)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene inverted formin 2 Neighboring gene adenylosuccinate synthase 1 Neighboring gene AKT serine/threonine kinase 1 Neighboring gene zinc finger and BTB domain containing 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of apoptosis-inducing factor (AIF) in the aged rat brain. Yu W, et al. Neurobiol Aging, 2011 Jan. PMID 19251341
  2. Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway. Py B, et al. J Immunol, 2004 Apr 1. PMID 15034012
  3. Expression of CD27 and ischemia/reperfusion-induced expression of its ligand Siva in rat kidneys. Padanilam BJ, et al. Kidney Int, 1998 Dec. PMID 9853261
  4. Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). Gudi R, et al. Oncogene, 2006 Jun 8. PMID 16491128
  5. The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva. Henke A, et al. Virology, 2001 Oct 10. PMID 11601913

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CD27 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CD27 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation-induced cell death of T cells ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apoptosis regulatory protein Siva
Names
CD27-binding protein
CD27BP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394537.1 → NP_001381466.1  apoptosis regulatory protein Siva

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P59692
    UniProtKB/TrEMBL
    A4FTX4, A6KBV7
    Related
    ENSRNOP00000034257.4, ENSRNOT00000031788.7
    Conserved Domains (1) summary
    pfam05458
    Location:1 → 177
    Siva; Cd27 binding protein (Siva)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    137526416..137530790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001100982.1: Suppressed sequence

    Description
    NM_001100982.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59692.1 GenPept UniProtKB/Swiss-Prot:P59692

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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