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PI31 Proteasome inhibitor 31 kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36277, updated on 2-Nov-2024

Summary

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Official Symbol
PI31provided by FlyBase
Official Full Name
Proteasome inhibitor 31 kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0033669
Locus tag
Dmel_CG8979
See related
AllianceGenome:FB:FBgn0033669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
8979; cg8979; CG8979; Dmel\CG8979; dmPI31; DmPI31
Summary
Predicted to enable endopeptidase inhibitor activity and proteasome binding activity. Involved in several processes, including male gonad development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of proteasome assembly. Located in sperm individualization complex. Is expressed in several structures, including adult head; imaginal disc; male germline cell; and testis. Orthologous to human PSMF1 (proteasome inhibitor subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See PI31 in Genome Data Viewer
Location:
48D5-48D5; 2-65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11967343..11970115, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7854848..7857620, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44305 Neighboring gene long non-coding RNA:CR44312 Neighboring gene expansion Neighboring gene ADD domain-containing protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease. Merzetti EM, et al. Genome, 2017 Jan. PMID 27936908
  2. Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth. Balakrishnan M, et al. Cell Rep, 2020 Jul 21. PMID 32697999, Free PMC Article
  3. Finding differentially expressed regions of arbitrary length in quantitative genomic data based on marked point process model. Hatsuda H. Bioinformatics, 2012 Sep 15. PMID 22962492, Free PMC Article
  4. PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, et al. Dev Cell, 2019 Aug 19. PMID 31327739, Free PMC Article
  5. Tankyrase Mediates K63-Linked Ubiquitination of JNK to Confer Stress Tolerance and Influence Lifespan in Drosophila. Li P, et al. Cell Rep, 2018 Oct 9. PMID 30304683

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables proteasome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteasome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in sperm individualization complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome inhibitor 31 kDa
Names
CG8979-PA
CG8979-PB
CG8979-PC
CG8979-PD
CG8979-PF
PI31-PA
PI31-PB
PI31-PC
PI31-PD
PI31-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11967343..11970115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273976.2 → NP_001260905.1  proteasome inhibitor 31 kDa, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260905.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZD9, Q0E9B8, Q9V637
    UniProtKB/TrEMBL
    A0A0B4KEK7
    Conserved Domains (1) summary
    pfam11566
    Location:23 → 159
    PI31_Prot_N; PI31 proteasome regulator N-terminal

  2. NM_136871.4 → NP_610715.1  proteasome inhibitor 31 kDa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZD9, Q0E9B8, Q9V637
    UniProtKB/TrEMBL
    A0A0B4KEK7
    Related
    FBpp0087157
    Conserved Domains (1) summary
    pfam11566
    Location:23 → 159
    PI31_Prot_N; PI31 proteasome regulator N-terminal

  3. NM_001273978.2 → NP_001260907.1  proteasome inhibitor 31 kDa, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZD9, Q0E9B8, Q9V637
    UniProtKB/TrEMBL
    A0A0B4KEK7
    Conserved Domains (1) summary
    pfam11566
    Location:23 → 159
    PI31_Prot_N; PI31 proteasome regulator N-terminal

  4. NM_165855.3 → NP_725093.1  proteasome inhibitor 31 kDa, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZD9, Q0E9B8, Q9V637
    UniProtKB/TrEMBL
    A0A0B4KEK7
    Related
    FBpp0087158
    Conserved Domains (1) summary
    pfam11566
    Location:23 → 159
    PI31_Prot_N; PI31 proteasome regulator N-terminal

  5. NM_165854.3 → NP_725092.1  proteasome inhibitor 31 kDa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZD9, Q0E9B8, Q9V637
    UniProtKB/TrEMBL
    A0A0B4KEK7
    Related
    FBpp0087159
    Conserved Domains (1) summary
    pfam11566
    Location:23 → 159
    PI31_Prot_N; PI31 proteasome regulator N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEK7 A0A0B4KEK7
Q9V637.1 Q9V637

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