Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ppp2r3cprovided by RGD
Full Name: protein phosphatase 2, regulatory subunit B'', gammaprovided by RGD
Primary source: RGD:1309207
See related: EnsemblRapid:ENSRNOG00000023591 AllianceGenome:RGD:1309207
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309207
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in cytoskeleton organization; lymphocyte homeostasis; and positive regulation of B cell differentiation. Predicted to act upstream of or within several processes, including activation of protein kinase activity; regulation of mitochondrial depolarization; and spleen development. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in spermatogenic failure 36. Orthologous to human PPP2R3C (protein phosphatase 2 regulatory subunit B''gamma). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Testes (RPKM 286.7), Thymus (RPKM 155.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6q23

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (78382849..78406037, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (72647025..72670885, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (76056585..76079755, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA945734 (e-PCR)
- UniSTS:250427

RH139091 (e-PCR)
- UniSTS:221177

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of B cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of antimicrobial humoral response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of antimicrobial humoral response	ISO Inferred from Sequence Orthology more info
involved_in regulation of dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in spleen development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014196.1 → NP_001014218.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

See identical proteins and their annotated locations for NP_001014218.1

Status: PROVISIONAL

Source sequence(s)

BC079257

UniProtKB/Swiss-Prot

Q6AXZ3

UniProtKB/TrEMBL

A0A8I6GFC5

Related

ENSRNOP00000087649.2, ENSRNOT00000114696.2

Conserved Domains (1) summary

cd21505
Location:56 → 437

PPP2R3C; serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma