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Zip48C Zinc/iron regulated transporter-related protein 48C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36273, updated on 9-Dec-2024

Summary

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Official Symbol
Zip48Cprovided by FlyBase
Official Full Name
Zinc/iron regulated transporter-related protein 48Cprovided by FlyBase
Primary source
FLYBASE:FBgn0033665
Locus tag
Dmel_CG13189
See related
AllianceGenome:FB:FBgn0033665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg13189; CG13189; Dmel\CG13189; dZip48C; ZIP48C
Summary
Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; amnioserosa; embryonic Malpighian tubule; embryonic proventriculus; and embryonic/larval salivary gland. Orthologous to human SLC39A11 (solute carrier family 39 member 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Zip48C in Genome Data Viewer
Location:
48C5-48C5; 2-65 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11899517..11901394)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7787022..7788899)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene cutoff Neighboring gene ncRNA Neighboring gene Endoplasmic reticulum p60 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene Microcephalin Neighboring gene rebuf Neighboring gene long non-coding RNA:CR44305

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. Lee WS, et al. J Clin Invest, 2022 May 2. PMID 35499073, Free PMC Article
  2. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. Rickmyre JL, et al. J Cell Sci, 2007 Oct 15. PMID 17895362
  3. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Dechen K, et al. Int J Biochem Cell Biol, 2015 Mar. PMID 25562517
  4. What can flies tell us about zinc homeostasis? Xiao G, et al. Arch Biochem Biophys, 2016 Dec 1. PMID 27136711
  5. A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila. Richards CD, et al. Arch Biochem Biophys, 2016 Dec 1. PMID 27453039

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc/iron regulated transporter-related protein 48C
Names
CG13189-PA
Zip48C-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11899517..11901394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136868.3 → NP_610712.1  Zinc/iron regulated transporter-related protein 48C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWW2, Q9V633
    Related
    FBpp0087144
    Conserved Domains (1) summary
    COG0428
    Location:23 → 340
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SWW2 Q8SWW2

Gene LinkOut

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