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Babam2 BRISC and BRCA1 A complex member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362704, updated on 27-Nov-2024

Summary

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Official Symbol
Babam2provided by RGD
Official Full Name
BRISC and BRCA1 A complex member 2provided by RGD
Primary source
RGD:735111
See related
EnsemblRapid:ENSRNOG00000004364 AllianceGenome:RGD:735111
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to be located in cytosol and nucleus. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 268.8), Heart (RPKM 137.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Babam2 in Genome Data Viewer
Location:
6q14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30089065..30467508, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (24369021..24788416, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (25666654..26135888, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene PYM homolog 1, exon junction complex associated factor, pseudogene 2 Neighboring gene FOS like 2, AP-1 transcription factor subunit Neighboring gene ribokinase Neighboring gene mitochondrial ribosomal protein L33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. Li L, et al. Biochem Biophys Res Commun, 1995 Jan 17. PMID 7826398
  2. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. Li Q, et al. J Biol Chem, 2004 Dec 10. PMID 15465831
  3. BRE: a modulator of TNF-alpha action. Gu C, et al. FASEB J, 1998 Sep. PMID 9737713
  4. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Shao G, et al. Genes Dev, 2009 Mar 15. PMID 19261746, Free PMC Article
  5. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Sobhian B, et al. Science, 2007 May 25. PMID 17525341, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables tumor necrosis factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
  
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
  
part_of BRCA1-A complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of BRISC complex IEA
Inferred from Electronic Annotation
more info
  
part_of BRISC complex ISO
Inferred from Sequence Orthology
more info
  
part_of BRISC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
BRISC and BRCA1-A complex member 2
Names
BRCA1-A complex subunit BRE
BRCA1/BRCA2-containing complex subunit 45
brain and reproductive organ-expressed (TNFRSF1A modulator)
brain and reproductive organ-expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199270.2 → NP_954891.1  BRISC and BRCA1-A complex member 2

    See identical proteins and their annotated locations for NP_954891.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q6P7Q1
    UniProtKB/TrEMBL
    A0A8I6A9B7, A6HA33
    Related
    ENSRNOP00000005855.5, ENSRNOT00000005855.6
    Conserved Domains (1) summary
    pfam06113
    Location:8 → 333
    BRE; Brain and reproductive organ-expressed protein (BRE)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    30089065..30467508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262050.1 → XP_063118120.1  BRISC and BRCA1-A complex member 2 isoform X3

  2. XM_039112461.2 → XP_038968389.1  BRISC and BRCA1-A complex member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P7Q1
    UniProtKB/TrEMBL
    A0A8I6A9B7, A6HA33
    Conserved Domains (1) summary
    pfam06113
    Location:8 → 333
    BRE; Brain and reproductive organ-expressed protein (BRE)

  3. XM_039112464.2 → XP_038968392.1  BRISC and BRCA1-A complex member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y9T9

  4. XM_006239802.4 → XP_006239864.1  BRISC and BRCA1-A complex member 2 isoform X1

    See identical proteins and their annotated locations for XP_006239864.1

    UniProtKB/Swiss-Prot
    Q6P7Q1
    UniProtKB/TrEMBL
    A0A8I6A9B7, A6HA33
    Conserved Domains (1) summary
    pfam06113
    Location:8 → 333
    BRE; Brain and reproductive organ-expressed protein (BRE)

  5. XM_039112465.2 → XP_038968393.1  BRISC and BRCA1-A complex member 2 isoform X4

    Conserved Domains (1) summary
    pfam06113
    Location:1 → 195
    BRE; Brain and reproductive organ-expressed protein (BRE)

  6. XM_039112463.2 → XP_038968391.1  BRISC and BRCA1-A complex member 2 isoform X2

    Conserved Domains (1) summary
    pfam06113
    Location:15 → 283
    BRE; Brain and reproductive organ-expressed protein (BRE)

  7. XM_039112468.2 → XP_038968396.1  BRISC and BRCA1-A complex member 2 isoform X4

    Conserved Domains (1) summary
    pfam06113
    Location:1 → 195
    BRE; Brain and reproductive organ-expressed protein (BRE)

RNA

  1. XR_010052102.1 RNA Sequence

  2. XR_010052101.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7Q1.1 GenPept UniProtKB/Swiss-Prot:Q6P7Q1

Gene LinkOut

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