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Faap20 FA core complex associated protein 20 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362678, updated on 4-Jan-2025

Summary

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Official Symbol
Faap20provided by RGD
Official Full Name
FA core complex associated protein 20provided by RGD
Primary source
RGD:1308923
See related
EnsemblRapid:ENSRNOG00000036876 AllianceGenome:RGD:1308923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308923
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin-modified protein reader activity. Predicted to be involved in interstrand cross-link repair and translesion synthesis. Predicted to be located in cell junction; chromatin; and nuclear body. Predicted to be part of Fanconi anaemia nuclear complex. Orthologous to human FAAP20 (FA core complex associated protein 20). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 48.4), Adrenal (RPKM 32.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Faap20 in Genome Data Viewer
Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171083328..171097599)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165808370..165815291)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172648171..172655576)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Ski proto-oncogene Neighboring gene uncharacterized LOC103692526 Neighboring gene protein kinase C, zeta Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Leung JW, et al. Proc Natl Acad Sci U S A, 2012 Mar 20. PMID 22396592, Free PMC Article
  2. Regulation of Rev1 by the Fanconi anemia core complex. Kim H, et al. Nat Struct Mol Biol, 2012 Jan 22. PMID 22266823, Free PMC Article
  3. FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Ali AM, et al. Blood, 2012 Apr 5. PMID 22343915, Free PMC Article
  4. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Yan Z, et al. Mol Cell, 2012 Jul 13. PMID 22705371, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-modified protein reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Fanconi anaemia nuclear complex ISO
Inferred from Sequence Orthology
more info
  
part_of Fanconi anaemia nuclear complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Fanconi anemia core complex-associated protein 20
Names
FANCA-associated protein of 20 kDa
Fanconi anemia core complex associated protein 20
Fanconi anemia-associated protein of 20 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108698.1 → NP_001102168.1  Fanconi anemia core complex-associated protein 20

    See identical proteins and their annotated locations for NP_001102168.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/Swiss-Prot
    D4AAA5
    UniProtKB/TrEMBL
    A0A8I6GGQ9
    Conserved Domains (2) summary
    pfam15750
    Location:151 → 182
    UBZ_FAAP20; Ubiquitin-binding zinc-finger
    pfam15751
    Location:34 → 142
    FANCA_interact; FAAP20 FANCA interaction domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171083328..171097599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239585.5 → XP_006239647.1  Fanconi anemia core complex-associated protein 20 isoform X1

    Related
    ENSRNOP00000088935.2, ENSRNOT00000108872.2
    Conserved Domains (2) summary
    pfam15750
    Location:212 → 243
    UBZ_FAAP20; Ubiquitin-binding zinc-finger
    pfam15751
    Location:95 → 203
    FANCA_interact; FAAP20 FANCA interaction domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4AAA5.1 GenPept UniProtKB/Swiss-Prot:D4AAA5

Gene LinkOut

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