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Twdlbeta Tweedlebeta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36265, updated on 9-Dec-2024

Summary

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Official Symbol
Twdlbetaprovided by FlyBase
Official Full Name
Tweedlebetaprovided by FlyBase
Primary source
FLYBASE:FBgn0033658
Locus tag
Dmel_CG8986
See related
AllianceGenome:FB:FBgn0033658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8986; CT25838; Dmel\CG8986; TwdlBeta
Summary
Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Twdlbeta in Genome Data Viewer
Location:
48C5-48C5; 2-65 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11862537..11863252, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7750042..7750757, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Megator Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Death associated molecule related to Mch2 caspase Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. Guan X, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075064, Free PMC Article
  2. A Novel Neuron-Specific Regulator of the V-ATPase in Drosophila. Dulac A, et al. eNeuro, 2021 Sep-Oct. PMID 34620624, Free PMC Article
  3. pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos. Stathopoulos A, et al. Genes Dev, 2004 Mar 15. PMID 15075295, Free PMC Article
  4. How do Wolbachia modify the Drosophila ovary? New evidences support the "titration-restitution" model for the mechanisms of Wolbachia-induced CI. He Z, et al. BMC Genomics, 2019 Jul 24. PMID 31340757, Free PMC Article
  5. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based cuticle ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in body morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chitin-based cuticle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tweedlebeta
Names
CG8986-PA
TwdlBeta
Twdlbeta-PA
tweedle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11862537..11863252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136863.4 → NP_610707.2  tweedlebeta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610707.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8Q0, Q8SZ76
    Related
    FBpp0087168
    Conserved Domains (1) summary
    smart00690
    Location:68 → 167
    DM5; Domain of unknown function, currently peculiar to Drosophila
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8Q0 A1Z8Q0
Q8SZ76 Q8SZ76

Gene LinkOut

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